Uvaria chamae is used in the treatment of sickle cell crisis Benin. The aim this work to determine safety roots aqueous extract wistar rats. was obtained by maceration. tests for Acute Oral Toxicity (AOT) and Sub-Chronic (SCT) respectively forced gavage a single dose 2000 mg / Kg 200 body weight 28 days were performed on female Wistar animals, serum creatinine, transaminases number white blood ...

PURPOSE Irinotecan is a prodrug converted to the active cytotoxic molecule SN38 predominantly by the action of liver carboxylesterases. The efficacy of irinotecan is limited by this hepatic activation that results in a low conversion rate, high interpatient variability, and dose-limiting gastrointestinal toxicity. The purpose of this study was to evaluate a novel peptidic prodrug of SN38 (DTS-1...

An experiment was conducted to study the effects of carbon tetrachloride (CCl4) on post-peak performance and serum enzymes of Hy-Line W-36 laying hens from 32-36 weeks of age. The experiment was carried out with a total of 192 laying hens in a completely randomized block design. During the experiment laying hens were allocated to 4 groups consisted of T1) no CCl4 as control diet, T2, T3 and T4)...

High doses of acetaminophen (APAP) result in hepatotoxicity that involves metabolic activation of the parent compound, covalent binding of the reactive intermediate N-acetyl-p-benzoquinone imine (NAPQI) to liver proteins, and depletion of hepatic glutathione. Impaired fatty acid β-oxidation has been implicated in previous studies of APAP-induced hepatotoxicity. To better understand relationship...

Publications concerning the protective effect of pectin against lead induced toxicity in rats are not available. In order to study such effect, 40 male were divided into 3 groups. The first group was contained 10 that kept as control group. second received at dose 100 mg/kg BW during experimental period (8 weeks). third 20 400mg/kg acetate daily for 4 weeks then two subgroups (3A and 3B). Subgr...

Iron oxide nanoparticles (IONPS) have potential different applications in nanomedicine. These new applications of IONPS have raised exposure risk of this nanomaterials to humans. Up to now, all aspects of IONPS toxicity are not fully clear following animal’s exposure with these novel compounds. This study aimed to investigate the acute toxicity effects of IONPS in laboratory animals regarding p...

Introduction: The principal dose-limiting factor in the use of cisplatin as an antineoplastic drug is its hepatic toxicity. This study was designed to investigate the protective role of taurine against cisplatin-induced hepatic injury. Methods: Male albino rats (180-220 g) were divided in to 4 groups (n=8) as follows: (1) saline-treated group (2): cisplatin-treated group (10 mg/kg ip) (3): g...

Background & Aim:Cadmium is an important industrial and environmental pollutant. Cadmium is one of the most toxic and carcinogenic heavy metals to organisms. This heavy metal mainly distributes to the liver and kidney in humans and animal and, causing acute hepatic injury. Experimental: The ethanol extract of Satureja hortensis L. (Lamiaceae family), was evaluated for its activity aga...

BACKGROUND Overall survival (OS) of patients with hepatic metastases of uveal melanoma is strongly linked with hepatic tumor control. Due to the lack of an effective systemic chemotherapy, locoregional therapies like radioembolization should play an increasingly important role. PURPOSE To report complications and response rates of radioembolization as salvage therapy for hepatic uveal melanom...

The effect of hepatic dysfunction, defined as abnormal serum bilirubin level, on oral cyclosporin (CSP) pharmacokinetics was examined in 28 marrow transplant patients who received CSP for prophylaxis of graft-v-host disease. Serum CSP concentrations were measured by radioimmunoassay. Forty-one concentration-time courses were studied, divided among patients with no (less than 1.2 mg/dL), mild (1...