OBJECTIVE To determine the extent of transmission of hepatitis C virus in sexual partners of intravenous drug misusers and to examine the relation between the prevalences of HIV, hepatitis B virus, and hepatitis C virus infections in homosexual men and intravenous drug misusers and their sexual partners. DESIGN Serum samples collected between 1984 and 1988 were tested for hepatitis B virus ma...

In this study a label-free electrochemical Immunosensor for ultrasensitive detection of Hepatitis C virus core antigen in serum samples was fabricated by using a simple approach. In this method a low-cost and sensitive immunosensor was fabricated based on a boehmite nanoparticles (BNPs) modified glassy carbon. The BNPs provide a specific platform with increased surface area which is capable of ...

background torque teno virus (ttv) belongs to the circoviridae family and was separated from japanese patients with elevated levels of serum alanine transferase for the first time. following this, extensive studies have been carried out around the world. objectives the present study was designed to investigate and determine the frequency of ttv genotypes in patients with chronic hepatitis b and...

context several risk factors play the role in the development of hepatocellular carcinoma (hcc) from which chronic hepatitis b and c infections are the most important ones. dna integration of hepatitis viruses alters the function of critical genes promoting malignant transformation of virus-infected liver cells. evidence acquisition there are remarkable geographic differences in prevalence of c...

aim and objectives: the hepatitis c virus (hcv) is essentially hepatotropic but virus compartment have also been found in other important extra hepatic sites. detection of hcv rna in extra hepatic reservoirs such as peripheral blood mononuclear cells (pbmcs) is important for determining of disease progression and effective treatment. the present study aimed to determining of different hcv genot...

background: beta-thalassemia patients have a high prevalence for hepatitis c virus (hcv) infection. in developing countries, hcv antibody is reported to be high in this group of patients. this study aims to determine the distribution of hcv amongst beta-thalassemia patients in northern iran. materials and methods: this study was undertaken from october 2010 to june 2011 on 245 beta-thalassemia ...

background: regulatory t cells (tregs) have been involved in impaired immunity and may have a pivotal role in persistence of viral infections. objective: to develop a simple and reliable in-house three color flow cytometery of peripheral blood to understand the role of hcv infection in the increase of tregs. methods: the level of naturally occurring cd4+cd25+foxp3+ regulatory t cells (ntregs) i...

conclusions this report highlighted the importance and the safety of this regimen to treat hcv in the elderly. case presentation here, a case of chronic hcv was described in a 65-year-old female with diabetes and low platelet count. the patient was treated successfully by a combination of sofosbuvir+ ribavirin without major side effects. introduction hepatitis c virus (hcv) is a major public he...

conclusions compared with monotherapy, adding ribavirin to treatment is more effective in removing hepatitis c virus from the bloodstream in patients with thalassemia, it is also more effective in reducing the relapse rate after treatment. except the increase in blood transfusion, there was no significant increase in side effects followed by adding ribavirin. results three randomized clinical t...