Hepatocellular carcinoma (HCC) accounts for 85% of primary liver cancer, the third most common cause cancer-related deaths worldwide. Its incidence has been increasing in both men and women. In Western countries, high-calorie diets, mainly rich carbohydrates such as fructose, represent a significant concern due to their repercussions on population’s health. A high-fructose diet is related devel...

positron emission tomography (pet) imaging using 2-deoxy-2-[f-18]fluoro-d-glucose (fdg) has proven valuable in the diagnosis, staging and restaging for many cancers. however, its application for liver cancer has remained limited owing in part to the relatively high background uptake of the tracer in the liver plus the significant variability of the tumor specific uptake in liver cancer among pa...

two set of 2-aryl-5,6-dihydropyrrolo[2,1-a] isoquinolines were designed and synthesized to evaluate their biological activities as topoisomerase inhibitors. cytotoxic activity of the synthesized compounds 4a-e and 7a-d was assessed against several human cancer cell lines, including mcf-7 (breast cancer cell), hepg2 (liver hepatocellular cells), a549 (adenocarcinomic human alveolar basal epithel...

5-fluorouracil (5-FU)-based chemotherapy is widely used in the treatment of human hepatocellular carcinoma. However, despite impressive initial clinical responses, the majority of patients eventually develop resistance to 5-FU. The microRNA (miR)-125 family has been implicated in a variety of carcinomas as either a tumor suppressor or promoter. In the present study, the role of miR-125b in acqu...

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and main cause of cancer-related death worldwide. The available treatment options for HCC include transplant, locoregional therapy (such as ablation, embolization, radiotherapy), systemic treatment. latter encompasses targeted therapy, immunotherapy, angiogenesis inhibitors, alone or in combination. introduction immune check...

Human cystic echinococcosis is a zoonosis caused by the larval cestode Echinococcus granulosus. Hepatocellular carcinoma is one of the most common types of cancer in the whole world including China. A few reports about cystic echinococcosis concurrent with hepatocellular carcinoma were noted until now. In addition, the association between these two diseases is still not well defined as the case...

Human hepatocellular carcinoma is one of the most common recurrent malignancies, for as much as, there is no effective therapy. Silibinin, a widely used drug and supplement for various liver disorders, demonstrated anticancer effects against human hepatocellular carcinoma, human prostate adenocarcinoma cells, human breast carcinoma cells, human ectocervical carcinoma cells, and human colon canc...

Human hepatocellular carcinoma is one of the most common recurrent malignancies, for as much as, there is no effective therapy. Silibinin, a widely used drug and supplement for various liver disorders, demonstrated anticancer effects against human hepatocellular carcinoma, human prostate adenocarcinoma cells, human breast carcinoma cells, human ectocervical carcinoma cells, and human colon canc...

Highly up-regulated in liver cancer (HULC) was originally identified as the most overexpressed long non-coding RNA in hepatocellular carcinoma. Since its discovery, the aberrant up-regulation of HULC has been demonstrated in other cancer types, including gastric cancer, pancreatic cancer, osteosarcoma and hepatic metastasis of colorectal cancer. Recent discoveries have also shed new light on th...