More than 90% of all liver malignancies are hepatocellular carcinomas (HCCs), for which chemotherapy and immunotherapy the ideal therapeutic choices. Hepatocellular carcinoma is descended from other diseases, such as viral hepatitis, alcoholism, metabolic syndrome. Normal cells tissues may suffer damage common forms chemotherapy. In contrast to systemic chemotherapy, localized can reduce side e...

BACKGROUND More than 50% of the worldwide cases of hepatocellular carcinoma occur in China, and this malignancy currently represents the country's second leading cause of cancer death in cities and the leading cause in rural areas. Despite recent advances in the control and management of hepatocellular carcinoma within China, this disease remains a major health care issue. The global HCC BRIDGE...

PURPOSE Recent studies have shown that Dickkopf-1 (DKK-1) is overexpressed in some tumors, including hepatocellular carcinoma. However, the role of increased DKK-1 in these tumors is not known. In this study, the DKK-1 expression in hepatocellular carcinoma (HCC) cell lines was evaluated and the effect of DKK-1 overexpression in HCC cell lines was studied. MATERIALS AND METHODS The expression...

Hepatocellular carcinoma (HCC) is the most common, malignant tumor of the liver. Hepatocellular carcinoma (HCC) commonly metastasizes to the lungs, abdominal lymph nodes, adrenal glands, or bones. Distant lymph node metastases are rare in hepatocellular carcinoma. A 49-year-old male patient presented with right sided neck mass. On examination there was right cervical lymphadenopathy and hepatom...

background : data mining has an interdisciplinary field including various scientific disciplines such as: database systems, statistics, machine learning, artificial intelligence and the others. in the field of medical, data mining algorithms can help physicians to diagnose diseases and chose the best type of treatment. hepatocellular carcinoma has the most common type of liver cancer. given the...

Deregulated microRNAs (miRNAs) have been shown to play important roles in cancer progression as a result of changes in expression of their target genes. In this study, we investigated the expression of miR-16b in eight hepatocellular carcinoma (HCC) cell lines, revealed the roles of miR-26b on hepatocellular carcinoma (HCC) cell proliferation, migration, and invasion, and confirmed that EphA2 i...

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and has a poor prognosis. Epigenetic modification been shown to be deregulated during HCC development by dramatically impacting differentiation, proliferation function of cells. One important epigenetic DNA methylation which methyl groups are added cytosines without changing sequence itself. Studies found that methylated...

Hepatocellular carcinoma (HCC) was the sixth most common cancer and third cause of cancer-related deaths worldwide in 2020. Liver resection transplantation remain cornerstone for patients with early-stage disease represent only option potential cure HCC. However, fewer than 10% are considered suitable surgery at time diagnosis. Locoregional therapies, defined as minimally invasive image-guided ...

Sorafenib is a breakthrough in the medical treatment aiming to control hepatocellular carcinoma (HCC) progression, but there some controversy patients' selection. The introduction of has led several positive effects. New more than promising antiangiogenic molecules have followed. Immunotherapy combined with therapy also strongly entered into HCC. All that induced significant guideline revision ...

Background: Hepatocellular carcinoma (HCC) is a major type of liver tumor. It represents up to 90% all malignancies. There are currently no reliable tumor markers or imaging technologies that can accurately diagnose early HCC. The use circulating micro-RNAs (miRNAs miR) as potential tool for detection HCC has become an emerging area study. Objectives: This study aimed evaluate the role miR-23b ...