The human bcr gene encodes a protein with serine/threonine kinase activity, CDC24/dbl homology, a GAP domain, and an SH2-binding region. However, the precise physiological functions of BCR are unknown. Coexpression of BCR with the cytoplasmic protein-tyrosine kinase encoded by the c-fes proto-oncogene in Sf-9 cells resulted in stable BCR-FES protein complex formation and tyrosine phosphorylatio...

background and aims. various morphologies are seen in different salivary gland tumorsor within an individual tumor, and the lesions show divers biological behaviors. experimental results support the hypothesis that increased crkii proto-oncogene is associated with cytokine-induced tumor initiation and progression by altering cell motility signaling pathway. the aim of this study was to assess t...

Gastrointestinal stromal tumors (GIST) are defined as mesenchymal of the gastrointestinal tract expressing proto-oncogene protein CD 117. GIST is a rare tumor small bowel, which can be difficult to diagnose and has varied clinical outcome. Prognosis dependent on size mitotic count. Radical surgical excision (R0) treatment choice for resectable non-metastatic disease. Imatinib first-line therapy...

PURPOSE The HER-2/erbB-2/c-neu (HER-2) proto-oncogene is a M(r) 185,000 transmembrane tyrosine kinase that is amplified and/or overexpressed by 20-40% of breast cancers. HER-2 has been associated with worse prognosis and resistance or sensitivity to specific treatment. We evaluated circulating levels of extracellular domain of HER-2 (ECD/HER-2) in metastatic breast cancer patients and investiga...

Buckwheat rutin has been found to be able to inhibit angiotensin II (AngII) - induced hypertrophy in cultured neonatal rat cardiomyocytes, but the mechanism remains uncertain. In this study, myocardial hypertrophy model was made by adding AngII to the medium of cardiac myocytes of neonatal rats; meanwhile, different concentrations of buckwheat rutin were applied to observe their effects. Intrac...

The successful treatment of breast cancer is dependent upon a number of complex factors. Her-2/neu gene amplification is known to be one of the most common genetic alterations associated with breast cancer and its accurate determination has become necessary for the selection of patients for trastuzumab therapy. The aim of this study was to prove the consistency of chromogenic in situ hybridisat...