Flavanones (hesperidin, naringenin, naringin, and poncirin) in industrial, hand-squeezed orange juices and from fresh-in-squeeze machines orange juices were determined by HPLC/DAD analysis using a previously described liquid-liquid extraction method. Method validation including the accuracy was performed by using recovery tests. Samples (36) collected from different Brazilian locations and bran...

Naturally multifunctional Rutaceae hesperidin and its aglycone hesperetin have a great variety of biopharmaceutical activities, e.g. anti-cancer, anti-inflammatory, antioxidant and antitumor; however, the influence of the molecular structures of hesperidin and hesperetin, and in particular, the structural properties such as flexibility and dynamic features of protein on the biological activitie...

1Among the numerous co-adjuvant therapies, which could influence the incidence and progression of diabetic complications, flavonoids, naturally occurring antioxidants, are currently being tested in several clinical and experimental trials. However, the protective efficiency of these compounds against complications in diabetic rat brain have rarely been investigated. 2The aim of the present stud...

Diabetes mellitus is a worldwide metabolic disorder with a rapidly increasing incidence. The International Diabetes Federation (IDF) has estimated the number of patients with diabetes to be 415 million in 2015. The IDF also expected that the number of diabetic patients will increase to 642 million by 2040[1]. The currently used therapeutic options for the management of diabetes has their own li...

BACKGROUND & AIMS Polyphenols exert a variety of biological properties, including antioxidant, immunomodulatory and antigenotoxic effects. In a randomized crossover study in healthy men, we investigated the effects of orange juice and its major polyphenolic compound hesperidin on a panel of immune cell functions, including cytokine secretion by leukocytes, lytic activity of NK cells, and the Re...

background: oxidative stress plays an important role in the pathogenesis and progression of γ-irradiation-induced cellular damage, lung is a radiosensitive organ and its damage is a dose-limiting factor in radiotherapy. the administration of dietary antioxidants has been suggested to protect against the succeeding tissue damage. the present study aimed to evaluate the radioprotective efficacy o...

BACKGROUND Ogi, one main component of boiogito (BOT), is reported to have an effect on hypercholesterolemia and NAFLD. In this experiment, we examined effects of ogi on the progression of hypercholesterolemia and fatty liver induced by high-cholesterol diet in rats and compared with the effects of ogi combined with ginger or hesperidin. METHODS Hypercholesterolemia and fatty liver were induce...