Protection against malaria in humans can be achieved by repeated exposure to infected mosquito bites during prophylactic chloroquine treatment (chemoprophylaxis and sporozoites (CPS)). We established a new mouse model of CPS immunization to investigate the stage and strain-specificity of malaria immunity. Immunization with Plasmodium chabaudi by mosquito bite under chloroquine cover does not ge...

In a previous paper (Hirose et al., 1962) it was reported that guinea pigs highly immunized against a bacterial suspension of Corynebacterium diphtheriae resisted to a challenge by the conjunctival method (Murata et al., 1959) with a toxinogenic virulent strain without even traces of antitoxic immunity, while a passive transfer of the immunity failed. The reason for this failure may have been d...

Schistosoma mansoni antigens in the early life alter homologous and heterologous immunity during postnatal infections. We evaluate the immunity to parasite antigens and ovalbumin (OA) in adult mice born/suckled by schistosomotic mothers. Newborns were divided into: born (BIM), suckled (SIM) or born/suckled (BSIM) in schistosomotic mothers, and animals from noninfected mothers (control). When ad...

The invertebrate's innate immune system was reported to show some form of adaptive features, termed trained immunity. However, the memory characteristics of innate immune system and the mechanisms behind such phenomena remain unclear. Using the invertebrate model Artemia, we verified the possibility or impossibility of trained immunity, examining the presence or absence of enduring memory again...

Persistence of immune memory in humans is a crucial yet poorly understood aspect immunology. Here we have studied the effect Puumala hantavirus infection on unrelated, pre-existing by studying T cell- and antibody responses against toxoid vaccine antigens diphtheria, tetanus pertussis cohort 45 patients. We found that tetanus- -specific IgG concentrations elevate during acute virus infection. I...

We have investigated the effect of preexisting immunity to homologous (Salmonella typhimurium) or heterologous (S. dublin) serotypes of Salmonella on the ability of an attenuated S. typhimurium aroA aroD vector (BRD509) to immunize mice against the heterologous antigen fragment C (FrgC). We studied two strains, BRD847 and BRD937, expressing FrgC carried on plasmids that differ only with respect...