نتایج جستجو برای: hev genotype prediction
تعداد نتایج: 344726 فیلتر نتایج به سال:
Background: Chronic hepatitis E virus (HEV) infection may progress to end-stage liver disease in immunosuppressed individuals. Ribavirin therapy is efficient most chronic HEV patients, but 10% remain without a sustained virological response (SVR). Objectives: We aimed study whether zinc supplementation could represent therapeutic approach these patients. Methods: Antiviral properties of salts w...
One of the five known hepatitis viruses that can infect humans is hepatitis E virus (HEV). The first documented infection that was caused by HEV occurred in 1955 during an outbreak in New Delhi, India (1). HEV is a small nonenveloped particle that belongs to the family Hep-eviridae and the genus Hepevirus. Its single-stranded RNA genome has approximately 7200 base pairs (2). By genomic sequence...
Prevalence of anti-hepatitis E virus (HEV) antibodies is highly variable in developed countries, which seems partly due to differences in assay sensitivity. Using validated sensitive assays, we tested 313 blood donors attending a hospital transfusion unit in central Italy in January and February 2014 for anti-HEV IgG and IgM and HEV RNA. Data on HEV exposure were collected from all donors. Over...
Hepatitis E virus (HEV) is one of the prime causes of acute viral hepatitis, and chronic hepatitis E is increasingly recognized as an important problem in the transplant setting. Nevertheless, the fundamental understanding of the biology of HEV replication is limited and there are few therapeutic options. The development of such therapies is partially hindered by the lack of a robust and conven...
Hepatitis E virus (HEV) constitutes a significant health burden worldwide, with an estimated approximately 33% of the world's population exposed to the pathogen. The recent licensed HEV 239 vaccine in China showed excellent protective efficacy against HEV of genotypes 1 and 4 in the general population and pregnant women. Because hepatitis E is a zoonosis, it is also necessary to ascertain wheth...
In Europe, the dynamics of endemic hepatitis E virus (HEV) infection remain enigmatic. We studied the presence of silent HEV infection among Dutch blood donors. Using donations collected throughout the Netherlands in 2011 and 2012, 40,176 donations were tested for HEV RNA in 459 pools of 48 or 480 donations. Deconstruction of the reactive pools identified 13 viraemic donors. In addition, 5,239 ...
We conducted seroepidemiological studies on antibody prevalence to hepatitis E virus (HEV) in 5,233 sera from 11 countries to ascertain the present state of HEV infection on a global basis. The prevalence of anti-HEV IgG increased with age in these tested countries, but the rate of antibody positivity was over 20% in the 16-30 year-old group in most of the participating countries, except for Ja...
Hepatitis E virus (HEV) is endemic worldwide and a major cause of acute liver disease in developing countries. However, the molecular mechanisms of liver pathology and clinical disease are not well understood for HEV infection. Open reading frame 3 (ORF3) of HEV encodes a small phosphoprotein, which is assumed to be involved in liver pathology and clinical disease. In this study, the interactio...
Hepatitis E virus (HEV) is an emerging pathogen and the most common cause of acute hepatitis. Five genotypes have been described to be capable of infecting humans (genotype 1, gt2, gt3, gt4, and gt7), and two genotypes (gt5 and gt6) have been described that only affect other animals. HEV typically causes an acute self-limiting illness, and not all infections develop overt clinical signs. After ...
BACKGROUND Chronic infection with hepatitis E virus (HEV) has recently been recognized in immunocompromised or immunosuppressed individuals. CASE REPORT We report a case of concurrent HEV and human herpes virus-6 (HHV-6) infection, documented by serum HEV RNA and HHV-6 DNA, in an orthotopic liver transplant (OLT) recipient in the United States, where HEV genotype 3 infection, although prevale...
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