Cannabinoids exhibit broad immune modulating activity by targeting many cell types within the immune system, including T cells, which exhibit sensitivity, as evidenced by altered activation, proliferation, and cytokine expression. As a result of the critical role calcium plays in T cell function coupled with previous findings demonstrating disruption of the calcium-regulated transcription facto...

Combinatorial auctions have been studied analytically for several years, but only limited experimental results are available, in particular for auctions with more than 10 items. We investigate the Hierarchical Package Bidding auction (HPB), the Combinatorial Clock auction (CC), and one pseudo-dual price auction (PDP) experimentally, as all these formats were used or suggested for high-stakes sp...

Dietary phenethyl isothiocyanate (PEITC) and a mixture of dietary PEITC and benzyl isothiocyanate (BITC) inhibit lung tumorigenesis in A/J mice induced by a mixture of the tobacco smoke carcinogens benzo[a]pyrene (B[a]P) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). In this study, we tested the hypothesis that inhibition of tumorigenesis by these isothiocyanates was due to inhibitio...

PURPOSE Pancreatic surgery is still thought as a challenging field even for experienced hepatobilliary (HPB) surgeons and high volume tertiary centers. The purpose of this study was to present the results (mortality and morbidity) of pancreatic surgery in a high volume center, in operations performed solely by inexperienced surgeons (two 6th year residents and a HPB fellow) under the supervisio...

We have fabricated a thin film of multilayered MnO2 whose interlayer is occupied with hexadecylpyridinium (HDPy) cations, using a simple anodic approach. The resulting film can effectively sorb iodide anions from aqueous solutions, even in the presence of NaCl or Na2SO4. The maximum sorption capacity was estimated to be 256 mg/g-MnO2, whereas a layered MnO2 film intercalated with K(+) ions show...

The tobacco-specific nitrosamine, 4-(methylnitrosamino)-l-(3-pyridyl)1-butanone (NNK), is considered to play an important role in the induc tion of lung cancer in tobacco users. In rats treated with [5--'H]NNK, 20 to 40% of the tritium bound to hemoglobin (Hb) is released by base hydrol ysis as 4-hydroxy-l-(3-pyridyl)-l-butanone (HPB). This HPB-releasing adduct has been quantified in tobacco us...

Biological markers for assessment of exposure to a variety of environmental carcinogens has been widely applied in both basic as well as clinical research. Exposure to tobacco smoke presents an ideal environment with which to develop, characterize, and refine biological markers, especially of those carcinogens found in tobacco. In the present study, a sensitive gas chromatography/mass spectrome...

List of the surgeons who responded to the questionnaire and conveyed their personal comments or suggestions: Surgery began to separate into individual specialities more than 30 years ago when Urology, Vascular and Plastic Surgery became independent entities in Euro-pe. Today, no one doubts the value of these divisions in view of the improved results obtained with patient management by specialis...

1. Minami Y, Kudo M. Radiofrequency ablation of liver metastases from colorectal cancer: a literature review. Gut Liver. 2013;7:1–6. 2. Razafindratsira T, Isambert M, Evrard S. Complications of intraoperative radiofrequency ablation of liver metastases. HPB (Oxford). 2011;13:15–23. 3. Frich L, Hol PK, Roy S, Mala T, Edwin B, Clausen OP, et al. Experimental hepatic radiofrequency ablation using ...