Repeated trauma, inadequate perfusion or oxygenation, excessive inflammation, infection, oxidative stress, anddiabetes all contribute to impaired wound healing. In a clinical setting, delay in healing may result severe complicationssuch as gangrene, leading extended hospitalization, amputation and even death of the patient. Slow andlimitations currently available synthetic medication, urges nee...

Diabetes mellitus is one of the most common non-communicable diseases that still growing today especially diabetes type 2 (DMT2). in non-obese patients an important problem to solve because it tends be worse than DM obese patients. Chronic hyperglycemia can damage body tissues through several mechanisms like polyol pathway, hexosamine activation protein kinase C (PKC) and advance glycation end ...

Hexosamine is a normal component of serum mucoprotein and its level may be regarded as an index of total mucoprotein which includes a, , and y globulins, fibrinogen, "seroglycoid," and cseromucoid." Interest in seromucoids was greatly enhanced when it was found by West and Clarke (1938) and others that in acute and chronic infections, in malignancy, and in a number of endocrine disturbances, th...

The canonical Wnt signalling pathway acts by slowing the rate of ubiquitin-mediated beta-catenin degradation. This results in the accumulation and subsequent nuclear translocation of beta-catenin, which induces the expression of a number of genes involved in growth, differentiation and metabolism. The mechanisms regulating the Wnt signalling pathway in the physiological context is still not ful...

To examine whether the hexosamine biosynthetic pathway might play a role in fat-induced insulin resistance, we monitored the effects of prolonged elevations in FFA availability both on skeletal muscle levels of UDP-N-acetyl-hexosamines and on peripheral glucose disposal during 7-h euglycemic-hyperinsulinemic (approximately 500 microU/ml) clamp studies. When the insulin-induced decrease in the p...

Qualitative and quantitative determinations of glycosaminoglycans in the nonswelling corneal stroma of the spiny dogfish shark, Squalus acanthias, were made with the use of a cetylpyridinium chloride-cellulose microfractionation technique. Dogfish stroma was found to contain predominantly highly sulfated galactosaminoglycans forming approximately 75 per cent of the total glycosaminoglycans when...