backgroud: protein-protein interaction, plays a key role in signal transduction in signaling pathways. different approaches are used for prediction of these interactions including experimental and computational approaches. in conventional node-edge protein-protein interaction networks, we can only see which proteins interact but ‘structural networks’ show us how these proteins interact which ca...

centralizing and using proper transportation facilities cut down costs and traffic. hub facilities concentrate on flows to cause economic advantage of scale and multimodal transportation helps use the advantage of another transporter. a distinctive feature of this paper is proposing a new mathematical formulation for a three-stage p-hub location routing problem with simultaneous pick-ups and de...

Scatter search is a population-based method that has been shown to yield high-quality outcomes for combinatorial optimization problems. It uses strategies for combining solution vectors that have proved effective in a variety of problem settings. In this paper, we present a scatter search implementation for an NP-hard variant of the classic p-hub median problem. Specifically, we tackle the unca...

The airlines reorganization will accelerate the switch of the Chinese mainland civil aviation system from a former point-to-point (PP) structure to a hub-and-spoke (HS) network. In such a context, the major efforts of our paper are put into identifying hub airports in mainland China. We first analyze the HS network’s competitive advantages and find four desirable hub characteristics. A three-le...

The aim of this paper is to provide insights for better modeling hub location problems help create a road map future research. We first present taxonomy framework the broad array models, and then seek identify key gaps in literature that opportunities models. some new perspectives several areas, including historical evolution research, models economies scale, relevant characteristics different ...

Recent studies show that fronto-posterior electroencephalogram (EEG) spectral power distribution is associated with personality. Specifically, extraversion is associated with an increase of spectral power in posterior cortical regions that overlap with the posterior default mode network (DMN) hub and a decrease of spectral power in anterior regions that overlap with the anterior DMN hub. Althou...

In hub-and-spoke systems, due to the changes in input parameters affecting system over time, transportation providers should make right and timely decisions about hub facilities. For this reason, multi-period location problems are especially important. This paper presents a comprehensive review of from 1990 up most recent published studies. First, we study developed models based on some charact...

A p-hub center network design problem consists of some nodes as hubs and allocation of non-hub nodes to them wherein the maximum travel times between any pair of nodes is minimized. The distinctive feature of this study is proposing a new mathematical formulation for modeling costs in a p-hub center problem. Here, instead of considering costs as a linear function of distance, for the first time...

The objective of this paper was to identify hub genes and pathways associated with retinoblastoma using centrality analysis of the co-expression network and pathway-enrichment analysis. The co-expression network of retinoblastoma was constructed by weighted gene co-expression network analysis (WGCNA) based on differentially expressed (DE) genes, and clusters were obtained through the molecular ...