introduction: osteosarcoma is the most common primary bone tumor in children and young adults and appropriate chemotherapy can increase limb sparing and overall survival. yet, the toxicity of chemotherapy regimens including mtx can be life threatening. therefore; we tried another chemotherapy regimen for these patients. method and materials: we investigated 15 patients aged 15 to 40 years old a...

Introduction: Oral squamous cell carcinoma (OSCC) is one of the 10 most common malignant tumors and SCC accounts 94% of all oral malignancies. Mast cells are regarded as complex and multifunctional cells, playing a significant role in immunopathology . The aim of this study is to evaluate the number of mast cells in tissue sections of oral squamous cell carcinoma (OSCC) in comparison with norma...

Malignant astrocytomas often display histopathological heterogeneity. In the present study, we have molecularly characterized different areas within 4 such tumors to determine whether the tissue heterogeneity can be explained by differences in DNA constitution. Two tumors contained low grade areas, and the other 2 had areas with satellites». The tumors were examined for loss of heterozygosity ...

Purpose: While the tumor microenvironment has been known to play an integral role in tumor progression, the function of nonresident bone marrow-derived cells (BMDC) remains to be determined in neurologic tumors. Here we identified the contribution of BMDC recruitment in mediating malignant transformation from low- to high-grade gliomas.Experimental Design: We analyzed human blood and tumor samp...

background and objective: male breast carcinoma (mbc) is an unusual form of neoplasia, representing 0.7 to 1 percent of all breast cancer cases. usually, the carcinoma affects patients after the sixth decade. the aim of this study was to evaluate the status of estrogen and progesterone receptors (er and pr) and prognostic factors (p53 and her-2/neu) in a series of male patients with breast canc...

intermediateand high-grade tumors; (iii) the term ‘tumor’ (neuroendocrine tumor, NET) is meant for lowto intermediate-grade neoplasms, as previously defined either ‘carcinoid’ or ‘atypical carcinoid’; (iv) the word ‘carcinoma’ (neuroendocrine carcinoma, NEC) is meant only for high-grade neoplasms, as previously defined poorly differentiated carcinomas. This terminology is adopted by the ENETS 2...

Ependymoma constitute 5 % to 7 % of all primary CNS neoplasm. But their prevalence relative to other tumor type varies with patient age and presenting location. Ependymoma constitute approximately 1O % of intracranial neoplasm in pediatric population and up to 30 % of those encountered in children under 3 years of age. In spinal column, ependymoma constitute 60% of glial neoplasm, and opposed...

High-grade osteosarcoma (OS) is characterized by low incidence, high aggressiveness and moderate 5-years survival rate after aggressive poly-chemotherapy and surgery. Here we used miRNA profiling as a tool to possibly predict and monitor OS's development and therapeutic outcome. First, we evaluated the altered expression of selected miRNAs from a case of Giant Cell Tumor (GCT) apparently evolve...