AIM To investigate the effects of phenytoin (DPH) on morphological and structural changes of pyramidal neurons in hippocampal CA3 of rats induced by chronic stress. METHODS Using Nissl staining, Golgi staining, and electron microscope, the morphology and structure of pyramidal neurons in hippocampal CA3 of rats were observed. RESULTS Chronic stress resulted in loss of hippocampal CA3 pyrami...

Survival and integration of new neurons in the hippocampal circuit are rate-limiting steps in adult hippocampal neurogenesis. Neuronal network activity is a major regulator of these processes, yet little is known about the respective downstream signaling pathways. Here, we investigate the role of cAMP response element-binding protein (CREB) signaling in adult hippocampal neurogenesis. CREB is a...

Introduction Neuronal cell death is an important factor in the pathogenesis of acute high-altitude cerebral hypoxia; however, underlying molecular mechanism remains unclear. In this study, we tested if hypoxia (HAH) causes neuronal and mitochondrial dysfunction using various vivo vitro approaches. Methods Acute was induced by hypobaric chamber male mice. explored mechanisms immunofluorescence, ...

Hippocampal neuronal activity distinguishes separate events that share common elements. Here, we examined whether the capacity to disambiguate overlapping experiences is an exclusive feature of hippocampal processing or whether information processing one stage earlier in the hippocampal system also disambiguates common elements of distinct experiences. We compared the spatial firing patterns of...

Microplastic particles in the blood can cause damage to organs such as brain. This study aimed analyze effect of microplastic on membrane (expression malondialdehyde metabolites) and deoxyribonucleic acid 8-hydroxy-2?-deoxyguanosine hippocampus neurons Wistar rats. Methods: Forty-two rats were used equally divided into six groups. The groups X1, X2, X3, X4 X5 was given 0.0375mg, 0.075mg, 0.15mg...

Surface micropatterns have been widely used as chemical cues to control the microenvironment of cultured neurons, particularly for neurobiological assays and neurochip designs. However, the cell-type dependency on the interactions between neurons and underlying micropatterns has been rarely investigated despite the inherent differences in the morphology of neuronal types. In this study, we used...