نتایج جستجو برای: hirschsprung
تعداد نتایج: 1258 فیلتر نتایج به سال:
Expression of the Ret receptor tyrosine kinase is a defining feature of enteric neurons. Its importance is underscored by the effects of its mutation in Hirschsprung disease, leading to absence of gut innervation and severe gastrointestinal symptoms. We report a new and physiologically significant site of Ret expression in the intestine: the intestinal epithelium. Experiments in Drosophila indi...
The transcription factor Sox10 is required for proper development of various neural crest-derived cell types. Several lineages including melanocytes, autonomic and enteric neurons, and all subtypes of peripheral glia are missing in mice homozygous for Sox10 mutations. Moreover, haploinsufficiency of Sox10 results in neural crest defects that cause Waardenburg/Hirschsprung disease in humans. We ...
Introduction: The aim of this study is to determine the incidence, morbidity and functional outcome of two techniques for Hirschsprung disease (single-stage Duhamel pull-through and tans-anal pull-through) in the neonatal age group. Method: All the neonates with Hirschsprung disease with short aganglionic segment (transition zone at recto-sigmoid junction) admitted during the last 6 years were ...
Enteric nervous system progenitor cells isolated from postnatal human gut and cultured as neurospheres can then be transplanted into aganglionic gut to restore normal patterns of contractility. These progenitor cells may be of future use to treat patients with Hirschprung's disease, a congenital condition characterized by hindgut dysmotility due to the lack of enteric nervous system ganglia. He...
In the management of chronic constipation Hirschsprung's disease may be diagnosed on the basis of radiological investigation, anorectal manometry, and rectal biopsy. Though x ray films and manometric studies may be highly suggestive, the definitive diagnosis requires rectal biopsy.' 2 The classical method of rectal biopsy involves taking a full thickness of rectal mucosa and underlying muscle, ...
hirschsprung's disease, also known as congenital aganglionic megacolon, is a congenital disorder which develops due to an absence of neural ganglia in a segment of large bowel. most commonly, the rectum or rectosigmoid, and rarely other areas or the entire colon are involved. in this disease, all three neural plexi, i.e., the myenteric (auerbach's) plexus, the superficial submucosal (...
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