The rough and tumble of John Howard’s public school education left him with an electorally appealing ordinariness in a party renowned for a born to rule attitude. Howard was not brought up with the sense of noblesse oblige of an establishment figure such as Malcolm Fraser. His father owned a small petrol station and John Howard worked there on weekends while at school. Howard’s background may h...

In places like contemporary China, where legal adjudication for past wrongdoings is impossible, an aesthetic engagement with the experience of loss has become essential to activating these historical remains and undermining violent narratives of progress. Tracing several generations’ aesthetic responses to the Cultural Revolution, the Tiananmen Square Massacre, and the present day influx of glo...

BACKGROUND The ATP7A gene encodes the ATP7A protein, which is a trans-Golgi network copper transporter expressed in the brain and other organs. Mutations in this gene cause disorders of copper metabolism, such as Menkes disease. Here we describe the novel and unusual mutation (p.T1048I) in the ATP7A gene of a child with Menkes disease. The mutation affects a conserved DKTGT1048 phosphorylation ...

Corporate culture is a key component in the achievement of an organization's mission and strategies, the improvement of organizational effectiveness, and the management of change. Culture is rooted in deeplyheld beliefs. It reflects what has worked in the past. It is a pattern of shared beliefs, attitudes, assumptions and values, which may not have been explicitly articulated. Corporate culture...

media can be a good representation of dominant ideologies in society. the analysis of such discourse can shed light on the mental and social structures of people in society. adopting van dijk’s (1995) layout of discourse ideology and his (2000) practical and general outline of ideological analysis, this study analyzes the iranian movie a separation, the winner of the 84th annual academy award f...

most charismatic figures of the 20th century public health and a typical representative of social medical ideology at the turn of 20th century. He was the founder of many health-related institutions in Croatia and world-wide. In 1927, with the help of a large grant from the Rockefeller Foundation, he opened the School of Public Health and the Institute of Hygiene in Zagreb. Andrija Štampar was ...

Both the amino-terminal and carboxyl-terminal domains of IGF binding protein (IGFBP)-3 are believed to contribute to high-affinity IGF binding. To investigate cooperativity in IGF binding by these domains, we expressed IGFBP-3 fragments 1-88 (NBP-3) and 185-264 (CBP-3) as FLAG and hexahistidine-tagged fusion proteins, respectively. IGF-I and IGF-II bound to NBP-3 poorly and to CBP-3 with modera...

The major light-harvesting chlorophyll a/b-binding protein (Lhcb1,2) of photosystem II is inserted into the thylakoid via the signal recognition particle dependent pathway. However, the mechanism by which the protein enters the membrane is at this time unknown. In order to define some topographical restrictions for this process, we constructed several recombinant derivatives of Lhcb1 carrying h...

Hairy root culture is a potential alternative to conventional mammalian cell culture to produce recombinant proteins due to its ease in protein recovery, low costs and absence of potentially human pathogenic contaminants. The current study focussed to develop a new platform of a hairy root culture system from Nicotiana tabacum for the production of recombinant human EPO (rhEPO), which is regula...