Rhp14 of Schizosaccharomyces pombe is homologous to human XPA and Saccharomyces cerevisiae Rad14, which act in nucleotide excision repair of DNA damages induced by ultraviolet light and chemical agents. Cells with disrupted rhp14 were highly sensitive to ultraviolet light, and epistasis analysis with swi10 (nucleotide excision repair) and rad2 (Uve1-dependent ultraviolet light damage repair pat...

Leptospirosis is a worldwide zoonosis caused by pathogenic Leptospira. The whole-genome sequence of L. interrogans serovar Copenhageni together with bioinformatics tools represent a great opportunity to search for novel antigen candidates that could be used as subunit vaccine against leptospirosis. We focused on six genes encoding for conserved hypothetical proteins predicted to be exported to ...

Intracellular delivery of functional macromolecules using peptide transduction domains (PTDs) is an exciting technology with both experimental and therapeutic applications. Recent data indicate that PTD-mediated transduction occurs via fluid-phase macropinocytosis involving an intracellular pH drop to approximately 5. Nitrilotriacetic acid (NTA)-coordinated metals avidly bind hexahistidine-tagg...

in any classical risk model one of the important random variable is time to ruin. as time to ruin warns the management for possible adverse situations that may arise, the distribution of time to ruin place a vital role in the day to day transactions of the any insurance company. moments of the distribution are also important as coefficient of skewness of the distribution is very important in ac...

regarding the formative period of shi'i islam and shi'i intellectual history, seyyed hosein modarresi tabatabayi in his work (“maktab dar farayande takamol”) proposed a plan according to which he claimed that some of the shi'i traditions (ahadith) which are not consistent with his plan, are fictitious. examining the sufficiency and correctness of his arguments, we can classify hi...

We impose the axiom Independence of Irrelevant Alternatives on division rules for the conflicting claims problem. With the addition of Consistency and Resource Monotonicity, this characterizes a family of rules which can be described in three different but intuitive ways. First, a rule is identified with a fixed monotone path in the space of awards, and for a given claims vector, the path of aw...

this paper provides a critical analysis of heidegger’s brief remarks in his “letter on humanism” in which he links ethics to ethos and ultimately to our relation to time and history. central to this analysis is the phrase of heraclitus, ēthos anthrōpōi daimōn, from which heidegger claims that human living (ethos) is inseparable from the event of appropriation (ereignis) which generates our hist...