Background In adult patients with chronic urticaria (CU), the prevalence of food allergy is low compared to childhood patients. However, there are many patients who report food-related aggravation of CU, and some of them may have histamine intolerance. Objective The aim of this study was to evaluate the role of ingested histamine and to investigate the effect of a histamine-free diet in adult...

Previous studies on the fate of histamine in the mammalian organism have shown that the substance can be rapidly inactivated (l), although some free histamine may be excreted in the urine, the amount depending on the species (2). The disruption in v&o of the imidazole ring of histamine has not been established nor has an accounting been made of all administered histamine in terms of known metab...

Serotonin and histamine H1, H2 receptor agonists or antagonists inhibited [3H]histamine uptake by HL-60 cells, according to the following order of potency: impromidine greater than 4-MH greater than histamine greater than AET greater than PEA and: cimetidine, histamine greater than diphenhydramine, serotonin. It is concluded that histamine uptake by HL-60 cells was specifically controlled by th...

Aryl hydrocarbon receptor (AhR) is a transcription factor that plays crucial role in skin homeostasis, regeneration and barrier. Tapinarof, an agonist of AhR, was reported to improve pruritus patients with atopic dermatitis; however, the AhR regulating itch remains unknown. Therefore, we aimed investigate regulation. Pruritogens, including histamine, chloroquine, trypsin serotonin were intrader...

Histamine is an important agent of innate immunity, transiently increasing the flux of immune-competent molecules from the vascular space to the tissues and then allowing rapid restoration of the integrity of the endothelial barrier. In previous work we found that histamine alters the endothelial barrier by disrupting cell-cell adhesion and identified VE-cadherin as an essential participant in ...

Histamine regulates a variety of physiological or pathophysiological processes via the activation of G(q/11) protein-coupled and Ca(2+)-mobilizing histamine H(1) receptors, including smooth muscle contraction. We have found that histamine induces progression from heterologous to homologous desensitization of contraction under normal physiological conditions in smooth muscle of guinea pig taenia...

We previously demonstrated that newly formed intracellular histamine mediates platelet aggregation in response to phorbol-12-myristate-13-acetate (PMA). We now report further investigations of the role of histamine during physiological activation of platelets by collagen. Platelets stirred with collagen produced histamine; the rise in histamine precedes the onset of aggregation. The dose respon...

We have examined the effects of exogenous and intrasynaptosomal histamine on the GABA transport in rat brain synaptosomes. Exogenous histamine had no effect on GABA uptake, but inhibited veratridine-evoked GABA release. GABA uptake was susceptible to the modification of histamine synthesis in synaptosomes. The increase of synaptosomal histamine level by incubation under conditions favouring his...

During the immediate response to an inhaled allergen, there is an increase in the paracellular permeability of the airway epithelium.1 Histamine is an important agonist released during the immediate response to inhaled allergen. We hypothesized that histamine would increase human airway epithelial paracellular permeability and that it would do this by interrupting E-cadherin-based cell adhesion...

ABSTI~.CT Using a specific fluorimetric and biological method, the occurrence and distribution of histamine was investigated in man, various mammals, birds, reptiles, amphibians, bony and cartilaginous fishes, lancelets, tunicates, echinoderms, molluscs, and crustaceans. The anune was identified by. the fluorescence spectrum, by specific antihistaminics in the bioassay, by the comparison of the...