Homo-oligomerization of proteins is abundant in nature, and is often intimately related with the physiological functions of proteins, such as in metabolism, signal transduction or immunity. Information on the homo-oligomer structure is therefore important to obtain a molecular-level understanding of protein functions and their regulation. Currently available web servers predict protein homo-oli...

In this work, we have studied binding of Clonidine drug (C9H9Cl2N3) with zigzag single walled carbonnanotubes (SWCNT) (5, 0) by theoretical methods of theory using Gaussian 09 software package.Binding energies, NMR parameters and HOMO- LUMO Gap energy were calculated. Results frombinding energies indicate that it is possible thermodynamically to bind Clonidine drug to SWCNT.The calculated NMR p...

Chemokine receptors, a subclass of G protein coupled receptors (GPCRs), play essential roles in the human immune system, they are involved in cancer metastasis as well as in HIV-infection. A plethora of studies show that homo- and heterodimers or even higher order oligomers of the chemokine receptors CXCR4, CCR5, and CCR2 modulate receptor function. In addition, membrane cholesterol affects che...

Brain volume and cheek-tooth size have traditionally been considered as two traits that show opposite evolutionary trends during the evolution of Homo. As a result, differences in encephalization and molarization among hominins tend to be interpreted in paleobiological grounds, because both traits were presumably linked to the dietary quality of extinct species. Here we show that there is an es...

A re the differences between humans and other animals “one of degree and not of kind,” as Charles Darwin concluded in his book, The descent of man? Derek C Penn from UCLA and his co-authors claim that Darwin was mistaken [1] and that the profound biological continuity between human and nonhuman animals masks an equally profound discontinuity between human and nonhuman minds. Minor anatomical ch...

This paper describes a survey of normative agent-based social simulation models. These models are examined from the perspective of the foundations of social theory. Agent-based modelling contributes to the research program of methodological individualism. Norms are a central concept in the role theoretic concept of action in the tradition of Durkheim and Parsons. This paper investigates to what...

of an earlier human species (Homo erectus) in its size, robusticity, and lack of chin. It also shows features that ally it with later species, such as the relatively small teeth. While initially suggested as an ancestor for the Neanderthals, similarities were later noted between Mauer and remains from Arago (France), which are in turn often grouped with comparable MidPleistocene fossils from Eu...