In this issue of BioEssays, Mike Wallis presents the hypothesis that million-year-old arms races against viruses may have shaped evolution mammalian growth hormone and prolactin systems,[1] offering a new perspective on role endocrine factors as direct viral interactors in defense infections. The systems be uniquely placed sense. Although they follow daily cycles respond to external factors, bo...

Peptide analogues targeting various neuropeptide receptors have been used effectively in cancer therapy. A hallmark of adrenocortical tumor formation is the aberrant expression of peptide receptors relating to uncontrolled cell proliferation and hormone overproduction. Our microarray results have also demonstrated a differential expression of neuropeptide hormone receptors in tumor subtypes of ...

BACKGROUND Length and intensity of signal transduction via cytokine receptors is precisely regulated. Degradation of certain cytokine receptors is mediated by the ubiquitin ligase SCF(βTrCP). In several instances, Janus kinase (Jak) family members can stabilise their cognate cytokine receptors at the cell surface. PRINCIPAL FINDINGS In this study we show in Hek293 cells that Jak2 binding to t...

PERSPECTIVES AND SUMMARY .......................................................................... 534 PROTEIN COMPONENTS OF HORMONE-SENSITIVE ADENYLATE CYCLASE ............................................................................................ 535 Hormone Receptors and .4denylate Cy¢lase ............................................................ 535 Hormone Receptors Linked to Aden...

Steroid hormones (SHs) are lipophilic molecules derived from cholesterol and synthesized in the adrenal cortex (glucocorticoids, mineralocorticoids, and adrenal androgens), the testes (testicular androgens, oestrogen), and the ovary and placenta (oestrogens and progestagens or progestins). SHs reach their target cells via the blood, where they are bound to carrier proteins, and because of their...

Nuclear hormone receptors are ligand-regulated transcription factors that play critical roles in metazoan homeostasis, development, and reproduction. Many nuclear hormone receptors exhibit bimodal transcriptional properties and can either repress or activate the expression of a given target gene. Repression appears to require a physical interaction between a receptor and a corepressor complex c...