In order to predict the jetting and the subsequent buckling flow more accurately, a three dimensional melt flow model was established on a viscous, incompressible, and non-isothermal fluid, and a control volume-based finite volume method was employed to discretize the governing equations. A two-fold iterative method was proposed to decouple the dependence among pressure, velocity, and temperatu...

A two part study utilizing polyoxymethylene (POM) was undertaken to investigate a three stage process (melt-extrusion/annealing/uniaxial-stretching) (MEAUS) utilized to produce microporous films. In this report, the thermal annealing (second stage) and subsequent uniaxialstretching (third stage) results of selected POM films from two commercial resins, labeled D & F, are discussed. Specifically...

in this research, the effect of friction between the liquid metal and the sand mould wall and the effect of passage of liquid through a vertical bend and through a ceramic filter on the fluid flow and the melt velocity has been studied by measuring the velocity of the melt and direct observation of the liquid flow through the different parts of a naturally-pressurized running system. the fricti...

C C Modeling plastic impression compound (MPIC) is defined as a thermoplastic dental impression material composed of wax, rosin, resins, and colorants.1 Low-fusing compound (type 1) is used for border molding and impressions. Flow and reproducibility of surface detail are important characteristics of these materials.2 Border molding with MPIC can record accurate border detail; however, it can b...

Taste is the ability to determine flavor of substances like food, drug, etc. The aspect taste only occurs when drug get soluble in saliva. Firstly gets dispersible saliva then they show interaction with bud and perception occurred. above test receptor binds molecules generates electrical impulses from area brain that cranial nerves 7th ,9th 10th occurs. Currently varieties drugs are available c...

OBJECTIVE The aim of this study was to evaluate the applicability of POVACOAT™, a hydrophilic PVA copolymer, as a solid dispersion (SD) carrier for hot-melt extrusion (HME). METHODS Bifendate (DDB), a water-insoluble drug, was chosen as the model drug. DDB was hot-melt extruded by a co-rotating twin screw extruder with POVACOAT™. The SD formability of POVACOAT™ was investigated by varying the...

The work presented here was motivated by the premise that the amorphous state serves as a medium to study cocrystal formation. The molecular mobility inherent to amorphous phases can lead to molecular associations between different components such that a single crystalline phase of multiple components or cocrystal is formed. Cocrystallization pathways and kinetics were investigated from amorpho...

In present times, the pelletization technologies are giving much attention as they represent an efficient pathway for manufacture of new drug delivery system .It has good advantage over the conventional dosage form. Pelletization technique help in the formation of spherical beads or pellets having a diameter 0.5 -1.5 mm which can be eventually coated for preparation of modified release dosage f...

The aim of this study was to investigate the influence of pH, buffer species and ionic strength on the release mechanism of chlorpheniramine maleate (CPM) from matrix tablets containing chitosan and xanthan gum prepared by a hot-melt extrusion process. Drug release from hot-melt extruded (HME) tablets containing either chitosan or xanthan gum was pH and buffer species dependent and the release ...

In order to improve the aqueous solubility and dissolution of Tacrolimus (TAC), amorphous solid dispersions of TAC were prepared by hot melt extrusion with three hydrophilic polymers, Polyvinylpyrrolidone vinyl acetate (PVP VA64), Soluplus® and Hydroxypropyl Cellulose (HPC), at a drug loading of 10% w/w. Molecular modeling was used to determine the miscibility of the drug with the carrier polym...