BACKGROUND Breast cancer is one of the most frequently occurring cancers in women. In recent years, Dendrobium candidum has played a part in antihyperthyroidism and anticancer drugs. This study aims to examine the antitumor effect of D. candidum on breast cancer. METHODS Human breast cancer cell line MCF-7 and normal breast epithelial cell line MCF10A were used to observe the effects of D. ca...

adenosine receptor family especially a1 type is expressed in breast cancer cells in which p53 and caspase genes are wild-type. the aim of this study was to investigate the correlation between a1 receptor and either cell apoptosis or proliferation and also to recognize the relationship between this receptor and p53 and the expression of caspases 3, 8 and 9 in mcf-7 cell line. mcf-7 cells were tr...

PURPOSE The aromatase inhibitors letrozole and anastrozole have been approvedrecently as first-line treatment options for hormone-dependent advanced breast cancer. Although it is established that a proportion of patients who relapse on first-line tamoxifen therapy show additional responses to aromatase inhibitors, it has not been determined whether tumors that acquire resistance to aromatase in...

Cancer is the second leading cause of death worldwide. There always a huge demand for novel anticancer. New series pyrazole, pyridine, thiazole derivatives containing sulfonamide moiety were prepared and screened their antitumor activity against breast cancer cell line (MCF-7). The results this investigation revealed that compounds 3 8 had significant anticancer MCF-7 with IC50 values 19.2 14.2...

Background: It was well studied that HER2/ErbB2/p185 overexpression in human malignant cancers correlates with poor prognosis and chemo-resistance. Meanwhile, Genistein (4,5,7trihydroxyisoflavone), a major isoflavone component of soybeans and other leguminous plants, has been shown to exhibit a potent anti-proliferative effect on some sex hormone dependent cancers. Objective: The effects of gen...

Ferritin is a major iron storage protein and essential for iron homeostasis. It has a wide range of functions in the body including iron delivery, immunosuppression, angiogenesis, and cell proliferation. Ferritin is overexpressed in many cancer cells, but its precise role in cancer is unclear. In the present study, we examined the functional roles of ferritin in protecting the MCF-7 breast canc...

Spontaneous or therapeutic-ally induced progression of hormone-de pendent human breast cancer to a form not amenable to endocrine treatment has been frequently recorded in clinical settings. In an experi mental model system, we have changed the estrogen-dependent tumorigenicity of a human breast cancer cell line, MCF-7, to an independent state by stably introducing a model oncogene, y-ras", int...

Members of the bombesin-related family of peptides (BRPs) are mitogenic for a variety of cell types; however, a role for these peptides has not been previously described in human breast cancer. Early membrane receptor signal transduction mechanisms associated with bombesin action include phospholipase C-mediated inositol phospholipid hydrolysis and the elevation of cytosolic Ca2+ levels. We hav...

The oncogene N-ras has been found to be amplified (congruent to 20 copies) in the human breast carcinoma cell line MCF-7. The amplified sequences have been localized to a marker chromosome by in situ hybridization. Sublines of MCF-7, serially passaged in different laboratories, have marked variation in the degree of N-ras amplification. The differing degrees of amplification of N-ras are furthe...