extra-cellular levels (serum) of heat shock protein 70 is influenced by various stressors such as exercise and it has been shown that this protein affects the proinflammatory cytokines in human and animal samples. the aim of this study was to investigate the effect of endurance training on serum levels of proinflammatory cytokines (tnf-?, il-1?, il-6 and hsp70) in trained and untrained rats. fo...

dentin bonding agents (dba) have been used as root-end filling materials. present study evaluated the effects of polymerized dba on secretion of pro-inflammatory cytokines by normal human monocytes. in this study, monocytes were directly isolated from human peripheral blood, and exposed to cured scotch bond 1 (single bond) and prime and bond for 36 and 72 hours. secretion of il-1β and tnf-α in ...

Objective(s): Yu-Ping-Feng-San (YPFS) is a classical traditional Chinese medicine that is widely used for treatment of the diseases in respiratory systems, including chronic obstructive pulmonary disease (COPD) recognized as chronic inflammatory disease. However, the molecular mechanism remains unclear. Here we detected the factors involved in transforming growth factor beta 1 (TGF-β1)/Smad2 si...

Background: Correlations between bone marrow, heart, kidney, liver, skin and lung transplant rejection or survival with human cytokine gene polymorphisms have been described. There are also reports about the role of cytokines and Tumor Necrosis Factors-Alpha (TNF-α) on corneal transplant in animal models. Further studies are needed to clarify the role of cytokines in corneal allograft rejection...

Genetically modified mice carrying engrafted human tissues provide useful models to study human cell biology in physiologically relevant contexts. However, there remain several obstacles limiting the compatibility of human cells within their mouse hosts. Among these is inadequate cross-reactvitiy between certain mouse cytokines and human cellular receptors, depriving the graft of important surv...

autism is a severe neurodevelopmental disorder that characterized by abnormal bilateral social interaction, deficiency in verbal and nonverbal communication, restricted interests and repetitive behaviors .autism caused by the inappropriate immune response which released several cytokines. one of the most important and main causes of autism is a defect in, the formation of the neuronal synaptic ...

a central role for t cells and their cytokines in the pathogenesis of psoriasis has been proposed; however, there are controversies over the details of this issue. the goal of this study is to summarise currently available data on the importance of t cells in psoriasis pathogenesis. a  systematic  review  of  the  english  medical  literature  was  conducted  by  searching pubmed, embase, isi w...