In this report, a 32 year-old patient is reported who was suffering from recurrent genital herpes for 3 years and her disease could not be controlled with conventional treatment methods. But, application of Imiquimod 5% cream, 3 times a week for 3 months, proved very effective with no recurrence for up to 7 months. Since recurrent genital herpes is the result of some immunologic dysfunctions ca...

Background: The diagnosis of herpes simplex virus may requirevirological confirmation. Tzanck smear is an old, rapid, costeffective but nonspecific method that has been recently re-evaluatedas a method for the diagnosis of herpes virus infection. This studywas conducted to compare Tzanck smear and viral culture in thediagnosis of herpes simplex virus infection in patients clinicallysuspected to...

BACKGROUND Despite advances in surgical aggressiveness and conventional chemotherapy, ovarian cancer remains the most lethal cause of gynecologic cancer mortality; consequently there is a need for new therapeutic agents and innovative treatment paradigms for the treatment of ovarian cancer. Several studies have demonstrated that ovarian cancer is an immunogenic disease and immunotherapy represe...

INTRODUCTION Autoimmune diseases are complex diseases with genetic, endogenous and environmental etiologies. Viral infections have been postulated as one of the factors that may be the trigger of autoimmune diseases. METHODOLOGY Thyroid peroxidase (TPO) and thyroglobulin (TG) antibodies were measured before thyroidectomy in 100 subjects by chemiluminescence method, 50 of whom were autoimmune ...

Introduction The herpes zoster oticus results from the reactivation of varicella virus, a DNA virus Herpesviridae family with strictly human-to-human contamination, affecting geniculate ganglion facial nerve. manifestations shingles and post-herpes signs are associated psychiatric such as anxiety, insomnia depressive disorder. Shingles disorder share common features, decreased cellular immunity...

HSV-1 DNA was detected in 32 (30%) of 106 cerebrospinal fluid samples from patients with encephalitis. Cytomegalovirus, varicella-zoster virus, and human herpesvirus 6 (HHV-6) DNAs were each detected in three patients (3%); herpes simplex virus type 2 (HSV-2) and HHV-7 PCRs were negative. HSV detection was associated with seizure (P = 0.02), especially focal seizure (P = 0.0002), and pathologic...

The characteristic site-specific reactivation phenotypes of HSV-1 and HSV-2 depend upon the latency-associated transcript region. Increasing proportion of herpes simplex virus type 1 as a cause of genital herpes infection in college students. episodes of genital herpes in a Swedish STD population: a study of epidemiology and transmission by the use of herpes simplex virus (HSV) typing and speci...

2 Varicella-zoster virus (VZV) is a human alphaherpesvirus that infects sensory ganglia 3 and reactivates from latency to cause herpes zoster. VZV replication was examined in human 4 dorsal root ganglia (DRG) xenografts in mice with severe combined immunodeficiency using 5 multiscale correlative immunofluorescence and electron microscopy (IF-EM). These 6 experiments showed the presence of VZV g...

OBJECTIVES The aim of the present study was to assess the prevalence of Herpes Simplex virus, Epstein Barr virus and Human Papilloma virus -16 in oral lichen planus cases and to evaluate whether any clinical variant, histopathological or demographic feature correlates with these viruses. STUDY DESIGN The study was conducted on 65 cases. Viruses were detected immunohistochemically. We evaluate...