Nowadays, Stroke is regarded as the second major cause of death and third morbidity globally. The ischemic stroke (IS) among most fatal kind strokes. Thus, due to importance this subject, article aims analyze role fibrosis markers (matrix metalloproteinase-9, tissue inhibitor matrix metalloproteinases-1), cytokines (tumor necrosis factor-α, interferon-γ, monocytic chemoattractant protein-1) in ...

Increased expression of the cytokine interferon (IFN)-γ plays a pivotal role in vitiligo-induced depigmentation. However, the major source of IFN-γ in vitiligo patients and the mechanisms underlying melanocyte destruction are unknown. In this study, a large number of skin infiltrating IFN-γ+ cells and CD8+ T cells were detected in progressive vitiligo. Among the peripheral blood mononuclear cel...

Programmed cell death ligand 1(PD-L1) is expressed as an adaptive immune response to escape anti-tumor mechanisms in various cancer types, including melanoma. However, the complex regulating PD-L1 expression are not well understood. Our aim elucidate signaling and explore candidate inhibitors C8161, SK-MEL-2 lines (human melanoma) B16(mouse melanoma), LN229(human glioblastoma) were used. RT qPC...

Although the majority of smooth muscle neoplasms found in the uterus are benign, uterine leiomyosarcoma (LMS) is extremely malignant, with high rates of recurrence and metastasis. We earlier reported that mice with a homozygous deficiency for LMP2, an interferon (IFN)-γ-inducible factor, spontaneously develop uterine LMS. The IFN-γ pathway is important for control of tumor growth and invasion a...

Inflammatory bowel diseases are associated with dysregulated electrolyte and water transport and resultant diarrhea. Aquaporins are transmembrane proteins that function as water channels in intestinal epithelial cells. We investigated the effect of the inflammatory cytokine, interferon-γ, which is a major player in inflammatory bowel diseases, on aquaporin-1 expression in a mouse colonic epithe...

Objective(s): The effects of alpha linolenic acid (ALA) on tracheal responsiveness (TR), total protein (TP), phospholipase A2 (PLA2), immunoglobulin E (IgE), interleukin 4 (IL-4), interferon gamma (INF-γ) level and INF-γ/IL4 ratio in bronchoalveolar lavage fluid (BALF) of sensitized rats were examined.Materials and Methods: TR to methacholine and ovalbumin (OA), BALF levels of TP, PLA2 and IgE ...

BACKGROUND Interferon-induced 35-kDa protein (IFP35) plays important roles in antiviral defense and the progression of some skin cancer diseases. It can be induced by interferon-γ (IFN-γ) in multiple human cells. However, the mechanisms by which IFN-γ contributes to IFP35 induction remain to be elucidated. METHODS/PRINCIPAL FINDINGS We identified the transcription start sites of IFP35 by 5' r...

BACKGROUND Despite encouraging results with the proteasome inhibitor bortezomib in the treatment of hematologic malignancies, emergence of resistance can limit its efficacy, hence calling for novel strategies to overcome bortezomib-resistance. We previously showed that bortezomib-resistant human leukemia cell lines expressed significantly lower levels of immunoproteasome at the expense of const...

the immunogenicity of γ-irradiated tachyzoites of a highly virulent strain of toxoplasma gondii (rh strain) was investigated. immunized mice survived challenge infection and displayed increased interferon gamma (inf-γ ) production. on the other hand, nonimmunized controls died after 10 days and displayed a significantly decreased lymphoproliferative response to concanavalin a (con a). no tachyz...