Objective: A pharmacological model to study the human disease Retinitis Pigmentosa is N-methyl-N-nitrosourea (MNU) injection which results in retinal degeneration. Our objective autophagy and mitophagy status of cells this model. Materials methods: The reporter (MitoQC) mice (mCherry-GFP-LC3) have been used determine mitophagic autophagic flux retina after MNU injection. Retinal pigment epithel...

Fifty cases of sympathetic ophthalmia were examined histologically to determine the incidence and morphology of Dalén-Fuchs nodules. At least one well-defined Dalén-Fuchs nodule was identified in 18 (36%) of the eyes examined. Three types of lesions at the level of the retinal pigment epithelium were recognised. One type was found to consist of focal hyperplasia and aggregation of retinal pigme...

We compared aged adult and fetal retinal pigment epithelium (RPE) migration and proliferation in cell culture. Aged adult RPE resurfaced on dishes coated with human or mouse laminin, human or rat collagen I, human or mouse collagen IV, or human fibronectin. Resurfacing was best on bovine corneal endothelial cell extracellular matrix. Resurfacing was worst on mouse laminin. Fetal RPE resurfacing...

this paper presents a new three-dimensional curvelet transform based dictionary learning for automatic segmentation of intraretinalcysts, most relevant prognostic biomarker in neovascular age-related macular degeneration, from 3d spectral-domain optical coherencetomography (sd-oct) images. in particular, we focus on the spectralis sd-oct (heidelberg engineering, heidelberg, germany) system, and...