It is 25 years since Tim Hunt discovered cyclin, the oscillating protein that drives activation of cyclin-dependent kinases and entry into mitosis (Evans et al., 1983).

A trinomial is a polynomial in one variable with three nonzero terms, for example P = 6x + 3x − 5. If the coefficients of a polynomial P (in this case 6, 3,−5) are in some ring or field F , we say that P is a polynomial over F , and write P ∈ F [x]. The operations of addition and multiplication of polynomials in F [x] are defined in the usual way, with the operations on coefficients performed i...

Department of Geography, University of Victoria, Box 1700, Stn CSC, Victoria, British Columbia, Canada V8 W 2Y2 Raincoast Conservation Foundation, General Delivery, Denny Island, British Columbia, Canada V0T 1B0 Hakai Institute, Box 309, Heriot Bay, British Columbia, Canada V0P 1H0 Department of Anthropology, University of Utah, 270 S. 1400 E., Salt Lake City, UT 84112, USA Global Change and Su...

Kelly A. Hunt, MPP Ellen J. Weber, MD Jonathan A. Showstack, PhD, MPH David C. Colby, PhD Michael L. Callaham, MD From Research & Evaluation, Robert Wood Johnson Foundation, Princeton, NJ (Hunt, Colby); and the Division of Emergency Medicine, Department of Medicine (Weber, Callaham), Institute for Health Policy Studies and Department of Medicine (Showstack), University of California, San Franci...