INTRALESIONAL HYALURONIDASE WITH TRIAMCINOLONE FOR RECALCITRANT PRETIBIAL MYXEDEMA Abstract Pretibial myxedema resulting in progressively worsening cutaneous induration and expanding nodules can lead to pain, discomfort and functional impairment. Treatment of resistant lesions presents a special challenge whereby topical therapies are insufficient, and systemic therapies are met with poor toler...

It has been demonstrated that some strains of Aerobacter aerogenes and Achromobacter fischeri synthesized relatively large amounts of a mucopolysaccharide which was depolymerized by hyaluronidase (Warren, 1950, 1951). This synthesis is of special interest because the bacterial mucopolysaccharide (hyaluronic acid) depolymerized by hyaluronidase has been generally assumed to be limited to the cap...

The diffusion of toxins from the site of a bite into the circulation is essential for successful envenomation. Degradation of hyaluronic acid in the extracellular matrix (ECM) by venom hyaluronidase is a key factor in this diffusion. Hyaluronidase not only increases the potency of other toxins but also damages the local tissue. In spite of its important role, little attention has been paid to t...

Biting midges of the genus Culicoides transmit pathogens of veterinary importance such as bluetongue virus (Reoviridae: Orbivirus). The saliva of Culicoides is known to contain bioactive molecules including peptides and proteins with vasodilatory and immunomodulative properties. In this study, we detected activity of enzyme hyaluronidase in six Culicoides species that commonly occur in Europe a...

Biting midges of the genus Culicoides transmit pathogens of veterinary importance such as bluetongue virus (Reoviridae: Orbivirus). The saliva of Culicoides is known to contain bioactive molecules including peptides and proteins with vasodilatory and immunomodulative properties. In this study, we detected activity of enzyme hyaluronidase in six Culicoides species that commonly occur in Europe a...

Hyaluronidase (Wydase®) is a medical preparation of highly purified bovine testicular enzyme. The enzyme hydrolyzes hyaluronic acid, which usually limits diffusion by binding cells together. Thus, it is believed that hyaluronidase increases permeability and promotes the spread of local anesthetic. This accelerates the onset of akinesia, and also helps to reduce the increase in intraocular press...

A study of the uncharacterized serum inhibitors of hyaluronidase, first described half a century ago, was undertaken. Activity was measured against bovine testicular hyaluronidase using a microtiter-based assay and reverse hyaluronan substrate gel zymography. The predominant inhibitory activity was magnesium-dependent and could be eliminated by protease or chondroitinase digestion and by heat t...

During the past several years, an investigation has been made of the relationships between various hormones of the adrenal cortex, the enzyme hyaluronidase, and its substrate hyaluronic acid, with specific reference to tissue permeability and collagen diseases. As the studies progressed, several problems were investigated: (i) which fractions of the adrenal cortex were responsible for the resul...

Bacterial enzyme ‘Hyaluronidase’ is a complex polysaccharide degrading enzyme that cleaves â-GlcNAc-(14) glycosidic linkage of Hyaluronate (HA) by â-elimination process. It is synthesized by a spectrum of grampositive bacteria which serve as potential contributors to a multitude of infectious diseases in human beings. Especially, group A streptococcus bacteria (GAS) have evolved several orders...