Gold nanoparticles (GNPs) can effectively differentiate the unfolded and folded aptamer, and quench the fluorescence of terbium ternary complexes (Tb-complexes), thus the authors herein report a sensitive strategy for protein detection, using label-free aptamer, Tb-complexes and GNPs. In the presence of thrombin, the aptamer is inclined to form G-quartet, and the folded aptamer cannot adsorb on...

Introduction: To increase therapeutic ratio, using radio-sensitizers is recommended and nowadays some types of them are utilized clinically. In recent years, Gold nanoparticles (GNPs) were considered as radio-sensitizers in many studies due to high atomic number. Although theoretical works showed that GNPs have an insignificant effect at MV energies, some In-vitro and In-vivo s...

In recent years, numerous platforms have been developed for the detection of DNA sequences due to their great importance in biological analysis and application in biomedical fields. In recent two decades, gold nanoparticles (GNPs) have shown great application value in bioanalytical fields owing to their facile preparation methods and excellent optical properties. These properties are utilized t...

HIV is a retrovirus which belongs to the family of lentiviruses. From the beginning of the HIV epidemic almost 75 million people have been infected and about 36 million people have died of HIV. Globally, 35.3 million people were living with HIV at the end of 2012. Gold nanoparticles (A. indica-GNPs) were synthesized from leaf extract of Azadirachta indica by microwave assistance. Surface chemis...

Photomechanical nanocomposites embedded with light-absorbing nanoparticles show promising applications in photoresponsive actuations. Near infrared (nIR)-responsive nanocomposites based photomechanical soft actuators can offer lightweight functional and underexploited entry into soft robotics, active optics, drug delivery, etc. A novel graphene-based photomechanical soft actuators, constituted ...

iv ACKNOWLEDGMENTS I would like to thank my advisor Dr. Lili He for her full support and encouragement throughout my research. The experience I gained and opportunities I had in this lab greatly exceeded my expectations, for which I am grateful. I would also like to thank Dr. Decker and Dr. Zhang for being members on my committee and for their input on my thesis. I would finally like to thank D...

Gold nanoparticles (GNPs), which are generally thought to be bio-inert and non-cytotoxic, have become one of the most ideal nano-materials for medical applications. Once engulfed by phagocytes, the immunological effects of GNPs are still of concern and require detailed investigation. Therefore, this study explored the immunological significance of GNPs on TLR-mediated innate immunity in murine ...

Gelatin-capped gold nano particles (GNPs) of diameter 23, 28 and 36 nm were prepared and characterized as almost monodispersed, near-spherical solids. In acidic media, these GNPs at their very low concentration level (∼10(-13) M) catalyze the oxidation of hydrazine by the metallo-superoxide, [(NH(3))(4)Co(III)(μ-NH(2),μ-O(2))Co(III)(NH(3))(4)](NO(3))(4) (1). In the presence of a large excess of...

BACKGROUND The aim of this study was to investigate the protective role of intranasally administered substance P-loaded gelatin nanoparticles (SP-GNPs) against 6-hydroxydopamine (6-OHDA)-induced apoptosis in vitro and in vivo, and to provide a new strategy for treating brain pathology, such as Parkinson's disease. METHODS SP-GNPs were prepared by a water-in-water emulsion method, and their st...

An evanescent-field-coupled waveguide-mode (EFC-WM) sensor utilizes monolithic SiO2/Si/SiO2 sensing plates having a multilayered structure and is used to evaluate a blocking agent comprising poly(ethylene glycol)-based block copolymers. Factor IX (FIX) protein was detected using its aptamer, viz. FIX was immobilized on a glutaraldehyde-modified silica surface, and then treated with a biotinylat...