Figure 1: (a) Images of hydroxyapatite (HA) coated Mg (Left) and uncoated Mg (Right) for degradation study. (b) Degradation of HA coated Mg (Left) compared to uncoated Mg (Right) after 12 days of incubation in PBS. Uncoated Mg showed larger area of degradation and more degradation products (white particles surround the sample). (c,d) SEM image and EDX analysis of HA coated Mg after 12 days of d...

In this study, acicular nano-hydroxyapatite (n-HA) was used to make a new biomimetic composite with polyamide (poly hexamethylene adipamide) by a unique technique. The physical and chemical characteristics of the composites were tested. It was found that these synthesized n-HA crystals were similar to bone apatite in size, phase composition and crystal structure. The biomimetic n-HA crystals we...

In this study, a novel biocompatible hydroxyapatite (HA) was synthesized by using chitosan oligosaccharide (COS) as a template. These HA samples were studied by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM). The biocompatibility of HA samples was evaluated via cell viability, cell morph...

The aim of the present study was to analyze the immunological response of hydroxyapatite (HA) to RAW264.7 cells by determining HA-induced phagocytosis. Immunological parameters included in this study were the role of polymerization of actin and microtubule, protein kinase-C (PKC), nitric oxide (NO), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α). The results showed that HA were phag...

We have studied in vitro the effect of a hydroxyapatite (HA) tricalcium phosphate material coated with hepatocyte growth factor (HA-HGF) on cell growth, collagen synthesis and secretion of metalloproteinases (MMPs) by human osteoblasts. Cell proliferation was stimulated when osteoblasts were incubated with untreated HA and was further increased after exposure to HA-HGF. The uptake of [3H]-proli...

The effects of Ca, K, Na, calcite, and EDT A on Pb immobilization by hydroxyapatite [CaIO(P04)6(OHh; HAl were investigated. The stability of hydroxy pyromorphite [PbIO(P04MOHh; HPJ (a reaction product of HA with Pb) and the effectiveness of using HA to immobilize Pb in Pb-contaminated soils also were examined. Neither Na nor K affected Pb immobilization. Aqueous Ca and calcite slightly inhibite...

In recent years, research on titanium and its alloys had increased significantly for hard tissue replacement and dental applications due to their excellent mechanical properties such as high strength to weight ratio, low density and biocompatibility. However, there are some surface originated problems associated with titanium (Ti): poor implant fixation, lack of osseoconductivity, wear and corr...

Introduction poly(l-lactic acid) (PLLA) has been approved for clinical use by the US Food and Drug Administration (FDA); however, their stronger hydrophobicity and relatively fast degradation rate restricted their widespread application. In consideration of the composition of bone, the inorganic-organic composite has a great application prospect in bone tissue engineering. Many inorganic-organi...

Hydroxyapatite/tannic acid coating (HA/TA) were prepared on AZ31 magnesium alloys (AZ31) via chemical conversion and biomimetic methods. The characterization and properties of the coating were studied by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), corrosion testing, MC3T3-E1 cell proliferation assay, and MC3T3-E1 cell morphology o...

The aim of this study is to evaluate the biocompatibility and osteoconductivity in surgical defects of sheep tibias filled with 1% strontium-containing nanostructured hydroxyapatite microspheres (SrHA), stoichiometric hydroxyapatite without strontium microspheres (HA), or blood clots. Santa Ines sheep were subjected to three perforations on the medial side of the left tibia. The biomaterials we...