Measurement of biological markers that demonstrate distinguishable and regular changes from preto postdialysis states can enable necessary monitoring of dialysis efficacy and the level of renal function in patients with end-stage renal disease. In a report in this issue of Clinical Chemistry, Blicharz et al. (1 ) suggest that the measurement of biomarkers in saliva may be an effective alternati...

Saliva is secreted into the mouth at a rate of 0.3 to 0.4 ml per minute. Retained saliva in the mouth physiologically triggers swallowing to carry the saliva out of the mouth. Dawes (1983) have reported the volume of saliva in the mouth just before swallowing, the rate of swallowing, the volume swallowed per swallow, and the volume of saliva in the mouth just after swallowing. Clearance of mate...

When a constant dose of digoxin was administered orally over several days, the digoxin concentration in saliva and erythrocytes rose faster than in serum. Thus, the saliva/serum concentration ratio was below 1.0 after a single dose and above 1.0 in the steady state. The digoxin concentration was relatively high in "unstimulated" (more or less spontaneous) saliva and decreased with stimulation o...

Decreases in saliva secretion compromise food mastication and swallowing, reduce mucosal immune function, and increase the risk for oral diseases like dental caries. Chlorella is a green alga that contains a variety of nutrients including amino acids, vitamins, and minerals. In our previous study, Chlorella-derived multicomponent supplementation did not affect salivary flow rates in healthy you...

background: saliva is an alternative biological matrix in drug testing. it has several advantages in comparison with other biological fluids such as blood and urine. collection of saliva is simple, noninvasive and can be controlled under direct observation in drug abusers, or opium addicts.   methods: in the present study we report our experience with saliva collection, liquid-liquid extraction...

The presence of hyaluronan (HA), hyaluronidase and hyaluronidase inhibitors has been assayed in pure resting and stimulated parotid saliva and also in resting and stimulated mixed saliva utilizing an ELISA-type assay and its modifications. Results confirmed the presence of hyaluronan in all saliva specimens which generally decreased upon stimulation. Hyaluronan in parotid saliva was of high mol...