Sulfamethoxazole is metabolized by microsomal CYP2C9 to a hydroxylamine that is thought to be responsible for the relatively high incidence of hypersensitivity reactions associated with the drug. Accurate quantification of the hydroxylamine requires the loss of metabolite through autoxidation to be blocked with ascorbate. In this study, a partly nonenzymatically generated arylhydroxylated deriv...

The metabolism and toxicity of dapsone was compared in vitro and in vivo in rat, mouse and man. Metabolism was assessed by high-pressure liquid chromatography-mass spectrometry and methemoglobin formation has been used as a toxic endpoint. The greatest toxicity in vitro was seen in microsomes prepared from male Wistar rats (36.6 +/- 1.5% methemoglobin), although toxicity was also seen in micros...

Glucuronides of piperazine hydroxylamines are rarely reported in the literature, and even more rarely are their structures unambiguously identified. One major metabolite was detected by liquid chromatography/mass spectrometry-radioactivity in urine from monkeys treated with the aryl piperazine oral hypoglycemic agent 9-[(1S,2R)-2-fluoro-1-methylpropyl]-2-methoxy-6-(1-piperazinyl) purine hydroch...

The catalytic performances of titanium species in TS-1 zeolite for the hydroxylamine formation have been investigated using the density functional theory with the ONIOM scheme. The reaction process for making hydroxylamine is divided into two steps: (i) the H2O2 decomposition over the Ti species to produce the peroxo titanium species and (ii) the NH3 oxidation over the generated oxidizing speci...

The scanning electrochemical microscope ~SECM! was used to study the electrochemical reduction of nitric acid to hydroxylamine at modified glassy carbon ~GC! electrodes. The GC surface was modified by holding it at a negative potential in solutions of p-aminophenol, or p-phenylenediamine in 1.0 M nitric acid. The generated products were detected in generation/collection experiments with an SECM...

With the objective of establishing an overview limits hydroxylamine-induced acceleration Fenton process, impact processing conditions and water matrix composition on degradation persistent dyes is revealed in this work.

MnCl 2 ·4H O and Tiron (disodium 4,5-dihydroxy-1,3-benzenedisulfonate) rapidly remove from aqueous solution at pH 7.50–11.0 20–50 °C using hydroxylamine (NH OH) as reducing substrate acts an anti-corrosion anti-bacterial formulation.

The reaction of indole derivatives with cyanoacetic acid followed by treatment with DMFDMA gave the intermediate indolyl enaminonitriles (3). Further reaction with aminoguanidine yielded 5 ́-cyanomeridianin analogues (4). The same intermediate reacted with pmethoxyphenylhydrazine to give the pyrazolyl derivative (8). Treatment of (2E)-3-dimethylamino-2-(1H-indol-3-yl)-propenoate (3a) with hydrox...