Familial hypercholesterolemia is a common, inherited disorder of cholesterol metabolism that leads to early cardiovascular morbidity and mortality. It is underdiagnosed and undertreated. Statins, ezetimibe, bile acid sequestrants, niacin, lomitapide, mipomersen, and low-density lipoprotein (LDL) apheresis are treatments that can lower LDL cholesterol levels. Early treatment can lead to substant...

Hyperlipidemia in conjunction with uninephrectomy leads to renal injury in rats. It is unknown whether this is due to mesangial cell or podocyte injury and whether the injuries induced by hypercholesterolemia and hypertriglyceridemia share a similar pathogenesis. Therefore, renal effects of hypercholesterolemia were studied in male rats with dietary hypercholesterolemia compared with rats on a ...

Abstract: Hypercholesterolemia is a metabolism disorder characterized by increased or decreased lipid fraction in plasma. The of this research was to prove the effect Rice bran decrease total Cholesterol rate, ratio LDL / HDL and increase rate hypercholesterolemia male white rats (Rattus norvegicus). Research study pure experiment using post test randomized control design. Sample divided into f...

Familial Hypercholesterolemia (FH) is a genetic disorder, an expression of defect in the gene that responsible for production LDL-C receptor. The current study was designed to determine FH patients city Sulaymaniyah both sexes. included 213 samples, number males 99 and females 114, sexes ranged from (30-79) years.The results cholesterol, triglyceride, high density lipoprotein (HDL-C), low-densi...

AIMS This study hypothesized that activation of endothelial nucleotide oligomerization domain-like receptor protein with pyrin domain containing 3 (Nlrp3) inflammasomes directly produces endothelial dysfunction during hypercholesterolemia, which is distinct from its canonical roles in inflammation. RESULTS Acute hypercholesterolemia in mice was induced by intraperitoneal administration of pol...

Familial hypercholesterolemia (FH) is an inherited common autosomal Mendelian disorder of lipoprotein metabolism with a population prevalence of 1 in 500. FH is characterized by severely elevated levels of low-density lipoprotein cholesterol (LDL-C), which result in surplus deposition of cholesterol in tissues. This condition leads to premature at hero sclerosis and early-onset of coronary hear...

The predictive value of speckle tracking imaging (STI) for the assessment of cardiac function and clinical prognosis in patients with hypercholesterolemia was explored. One hundred forty-seven patients with hypercholesterolemia diagnosed in our hospital and 137 healthy adults from our health examination center over the same period were included in this study. Using STI and color Doppler ultraso...

OBJECTIVE To determine the common mutation of low density lipoprotein receptor in hypercholesterolemia patients requiring screening for heterozygous familial hypercholesterolemia (HeFH) in Karachi. STUDY DESIGN Case-series. PLACE AND DURATION OF STUDY Dr. Ziauddin Hospital Laboratory and Dr. Rubina Ghani's Pathological and Molecular Laboratories, Karachi, for the PCR bench work from June 20...

Endothelial regeneration after a narrow, superficial aortic injury was studied in rats with chronic Goldblatt hypertension, genetic hypercholesterolemia, or a combination of hypertension and genetic hypercholesterolemia. In all groups, endothelial continuity was restored within 24 to 36 hours by a combination of endothelial migration and proliferation. A line of increased endothelial density co...