Introduction:Type 1 diabetes mellitus (T1DM) is the most common metabolic disorder occurring in childhood with significant morbimortality. Uncontrolled diabetic patients are exposed to fatal hyperglycemic emergencies such as Diabetic ketoacidosis (DKA) characterized by hyperglycemia, acidosis, and ketosis. Although infections remain predominant precipitating factors for (DKA), its association m...

Aiming at the determination of the metabolic disorder prevalence as well as the effect of subclinical disorders on daily milk traits of Holsteins, over 1 million (1 962 831) test day records were analysed. The metabolic disorder (ketosis or acidosis) prevalence was indicated by the fat-to-protein (F/P ) ratio, while subclinical disorder was indicated by the F/P ratio and cows’ daily production....

OBJECTIVE This study was designed to test the accuracy of capillary ketonemia for diagnosis of ketosis after interruption of insulin infusion. RESEARCH DESIGN AND METHODS A total of 18 patients with type 1 diabetes treated by external pump were studied during pump stop for 5 h. Plasma and capillary ketonemia and ketonuria were determined every hour from 7:00 A.M. (time 0 min = T0) to 12:00 P....

OBJECTIVE Despite advances in exogenous insulin therapy, many patients with type 1 diabetes do not achieve acceptable glycemic control and remain at risk for ketosis insulin-induced hypoglycemia. We conducted a randomized controlled trial to determine whether TTP399, novel hepatoselective glucokinase activator, improved people without increasing hypoglycemia or ketosis. RESEARCH DESIGN AND METH...

OBJECTIVE Most aggressive cancers demonstrate a positive positron emission tomographic (PET) result using ¹⁸F-2-fluoro-2-deoxyglucose (FDG), reflecting a glycolytic phenotype. Inhibiting insulin secretion provides a method, consistent with published mechanisms, for limiting cancer growth. METHODS Eligible patients with advanced incurable cancers had a positive PET result, an Eastern Cooperati...

BACKGROUND Ketogenic diets are used therapeutically to treat intractable seizures. Clinically, it appears that the maintenance of ketosis is crucial to the efficacy of the diet in ameliorating seizures. To understand how ketosis and seizure protection are related, a reliable, noninvasive measure of ketosis that can be performed frequently with minimal discomfort is needed. OBJECTIVE The objec...

THE COMPLEXITIES of the diabetic syndrome are underlined by the fact that diabetic coma may occur without obvious ketoacidosis. The position has recently been summarised in a leading article in the British Medical Journal (1965). To the first two comas met with in diabetes, namely diabetic coma with ketosis and hypoglycaemic coma due to excess insulin, must then be added a third type of coma. T...

Many patients that present with cerebral ischemia exhibit moderate to severe hyperglycemia. Although many hyperglycemic patients suffer from diagnosed or previously undiagnosed diabetes a further subset of individuals is hyperglycemic without diabetes. Hyperglycemia during cerebral ischemia is associated with high levels of mortality and morbidity and limits the effective treatment intervention...

OBJECTIVE The incidence of cystic fibrosis-related diabetes (CFRD) and the prevalence of diabetic microvascular complications were determined at the University of Minnesota. RESEARCH DESIGN AND METHODS Cystic fibrosis patients have undergone annual oral glucose tolerance testing since 1990. Database review was performed to determine diabetes duration and the results of annual urine albumin-to...

BACKGROUND Ketosis is an important problem for dairy cows` production performance. However, it is still little known about plasma metabolomics details of dairy ketosis. RESULTS A gas chromatography/mass spectrometry (GC/MS) technique was used to investigate plasma metabolic differences in cows that had clinical ketosis (CK, n=22), subclinical ketosis (SK, n=32), or were clinically normal cont...