Abstract Hyperpigmentation is a common and major skin problem that affects people of all types. Despite the availability various depigmentation active ingredients for hyperpigmentation disorder, none them are completely satisfactory due to their poor permeability through layer significant toxicity, thereby causing severe side effects such as irritative dermatitis, erythema, itching, flaking. Na...

Background: Imatinib, a tyrosine kinase inhibitor targeting bcr-abl, c-Kit, and PDGF receptors-alpha beta, is commonly used to treat GI stromal tumors hematologic malignancies. Hyperpigmentation known side-effect of imatinib, with intradermal hemosiderosis being the most common histologic finding.
 Case Presentation: We report rare case concurrent hypopigmentation hyperpigmentation seconda...