OBJECTIVE Decreased bone mineral density has been found in the chronic schizophrenic patients who have been given a long-term administration of antipsychotics. Hyperprolactinemia from the antipsychotics and the negative symptom of schizophrenia were considered as the causes for this finding. In this study, the effect of hyperprolactinemia and the negative symptom of schizophrenia on bone minera...

There are numerous etiologies of hyperprolactinemia, a common reason for consultation. Diagnostic measures must be capable of identifying the tumors, the most frequent of which are prolactin adenomas. Hypothalamic-pituitary MRI is the reference morphological examination. In clinical practice, it is usually performed very early, following the discovery of increased plasma concentrations of PRL. ...

Quetiapine is an atypical antipsychotic agent with negligible prolactin-elevating properties. Although little data is available, studies show that it is both effective and safe in a variety of childhood mental illnesses. It has also been suggested to be the treatment of choice in antipsychotic-induced hyperprolactinemia in children. We report a case of a fourteen-year old male with conduct diso...

Prolactin presents important size heterogeneity in terms of circulating molecular forms. Besides the monomer (23kDa), which predominates in healthy subjects as well as in patients with prolactinoma, high molecular forms are also present in low concentrations (1). These high molecular forms include 50 kDa dimers (big prolactin) and also forms with even larger molecular weights (MW>150 kDa), know...

Identifying the correct cause of hyperprolactinemia is crucial for treatment. Prolactinoma is the most common pathologic cause of hyperprolactinemia. Dopamine agonists are efficacious in about 80% to 90% of patients with prolactinoma, leading to reduction of serum prolactin levels and tumor dimensions. Neurosurgery, mainly by the transsphenoidal route, is indicated in cases of intolerant and re...

I have reported the case of a woman with Sheehan's syndrome who had hyperprolactinemia rather than prolactin deficiency. The patient showed no increase in serum thyrotropin in response to TRH challenge and failed to show a normal increase in serum GH and cortisol after insulin-induced hypoglycemia. A blunted FSH response to LH-RH stimulation was also found. A CT scan of the sella showed no aden...

We have read with great interest the article “Relationship between plasma levels of prolactin and the severity of negative symptoms in patients with schizophrenia” written by Ates et al.. They aimed to investigate the relationship between prolactin levels of plasma and negative symptoms in patients with schizophrenia. They demonstrated that prolactin levels are positively correlated with the se...

SUMMARY OBJECTIVE: To assess the impact of metoclopramide-induced hyperprolactinemia in cellular death and proliferation harderian gland female mice. METHODS: Twenty mice were divided into two groups 10 animals each treated: 0.2 mL saline solution (controls, Ctr) 200 µg metoclopramide (experimental, hyperprolactinemia), both for 50 consecutive days at 12:00 a.m. On 50th day, euthanized, glands ...