We examined the lipoprotein lipase (LPL) gene by single strand conformation polymorphism (SSCP) and by restriction fragment length polymorphism (RFLP) analysis in 106 patients with hypertriglyceridemia to screen for novel mutations and to study the contribution of LPL genetic defects in hypertriglyceridemia. We found a single incidence of a homozygous novel nonsense mutation (216G-->A; -14Trypt...

BACKGROUND Recent data support the renewed interest in hypertriglyceridemia as a possible important therapeutic target for cardiovascular risk reduction. This study was designed to address the question of all-cause mortality during extended follow-up of the BIP trial in patients stratified by baseline triglyceride levels. METHODS In the BIP trial 3090 patients with proven coronary artery dise...

Introduction: L-asparaginase and corticosteroids are widely used in the chemotherapy of acute lymphoblastic leukemia (ALL). This combination is known to cause several adverse effects one which hypertriglyceridemia. Although condition asymptomatic reversible it can lead serious complications.

We have generated transgenic mice expressing the human apolipoprotein CII (apoCI ) gene under the transcriptional control of the human cytochrome P450 IA1 (CYPIAl) promoter. Human apoCIt transgenic (HuCIITg) mice exhibited significant basal expression of the transgene (plasma apoCIl level = 26.1±4 mg/dl) and showed further induction of transgene expression after treatment with fl-naphthoflavone...

Mice with type 2 diabetes manifest selective hepatic insulin resistance: insulin fails to suppress gluconeogenesis but continues to activate lipogenesis, producing the deadly combination of hyperglycemia and hypertriglyceridemia. In this issue of Cell Metabolism, Biddinger et al. (2008) show that mice with total hepatic insulin resistance exhibit hyperglycemia without hypertriglyceridemia-a sta...

Introduction Elevated serum triglycerides, total cholesterol, very lowdensity lipoprotein (VLDL) cholesterol, and low-density lipoprotein (LDL) cholesterol have been reported in the literature from areas where experience with antiretroviral drugs has amassed. Up until recently the use of antiretroviral drugs in Nigeria on a wide scale was a rarity owing largely to prohibitive cost, and so exper...

There are no conclusive data regarding the association between dyslipidemia and the risk of ischemic stroke (IS). Clinical investigations have primarily focused on the association between elevated levels of low-density lipoprotein cholesterol and low levels of high-density lipoprotein cholesterol as stroke risk factors. Much less scientific attention has been aimed at elevated levels of triglyc...

Introduction: Hypertriglyceridemia is recognized as a high-risk factor for coronary artery disease. It remains unclear whether fasting or postprandial hypertriglyceridemia more informative predicting the risk of Recent studies recommended useful predictor cardiovascular disease risk. This study was conducted to find correlation between in patients with Materials and Methods: an observational on...

conclusions metabolic abnormalities in bscl may prove fatal necessitating optimal therapeutic and preventive measures. patients are advised low fat diet with enhanced physical activities. other treatments include metformin, n-3 polyunsaturated fatty acids and leptin replacement for correction of metabolic complications. we report this case of bscl in view of its rarity. case presentation an 18 ...