Prostaglandin E1 (alprostadil) is widely used for maintaining the patency of ductus arteriosus in ductus-dependent congenital heart defects in neonates to improve oxygenation. Among more common side effects are fever, rash, apnoea, diarrhoea, jitteriness, and flushing. More severe side effects are brown fat necrosis, cortical hyperostosis, and gastric outlet obstruction, most commonly the resul...

BACKGROUND Infantile hypertrophic pyloric stenosis (IHPS) is a common cause of gastric outlet obstruction in infants. This study was conducted to identify the accuracy of ultrasonography in the diagnosis of infantile Hypertrophic pyloric Stenosis. METHODS This cross-sectional descriptive study was conducted in Department of Paediatric Surgery, Children Hospital Complex & the Institute of Chil...

Hypertrophic pyloric stenosis (HPS) is a common cause of non-bilious vomiting in infants. In USA, operation for HPS is one of the commonest surgical procedure performed on infants.1 Etiology remains poorly understood. A recent epidemiological survey from Sweden2 has noted a distinct difference in geographical distribution suggesting an environmental causation. A palpable pyloric 'tumor' is pres...

Introduction: Hypertrophic pyloric stenosis (HPS) is well known in pediatric surgery and has good outcomes after pyloromyotomy.1 Emesis the immediate postoperative period occurs 40% of patients with HPS attributed to gastroparesis from prolonged gastric distention.2 presenting weeks months pyloromyotomy prompts an evaluation that often yields pathology unrelated HPS. Because recurrent rare, mak...

IMPORTANCE Infantile hypertrophic pyloric stenosis (IHPS) is a serious condition in which hypertrophy of the pyloric sphincter muscle layer leads to gastric outlet obstruction. Infantile hypertrophic pyloric stenosis shows strong familial aggregation and heritability, but knowledge about specific genetic risk variants is limited. OBJECTIVES To search the genome comprehensively for genetic ass...

Simple, primary, or idiopathic hypertrophy of the pyloric muscle in the adult resembles the congenital pyloric hypertrophy of infants, and no associated lesion, such as a peptic ulcer, is apparent. The hypertrophy, which narrows and elongates the pyloric canal, is limited to the muscle of the pyloric sphincter and, most commonly, mainly involves the circular muscle; sometimes it is focal. The c...

Analyses of hospital records and census data for 1971-84 showed no significant increase in incidence of infantile hypertrophic pyloric stenosis in Western Australia. No link was found between breast feeding and incidence of disease. Low birth weight, short gestation pregnancies, and paternal family history of the disease were significant features.

Acquired gastric outlet obstruction (GOO) during infancy beyond the neonatal period is a very rare condition when other congenital causes like infantile hypertrophic pyloric stenosis, antral diaphragm, pyloric atresia etc are excluded. We report an unusual case of 6 month old male child who presented with recurrent episode of vomiting not relieved by medication. On gastrograffin study there was...

Conrad Ramstedt performed the first pyloromyotomy for what is now called idiopathic hypertrophic pyloric stenosis 100 years ago. The intervening century has seen the management of this condition transformed but the underlying cause remains a mystery. This article reviews the treatment of this condition before and after the introduction of pyloromyotomy and the advances made subsequently towards...

CONFEN~TAL hypertrophic pyloric stenosis has been linked with primogeniture in many reports since Still [l] first suggested that its incidence might be associated with birth rank. Principal contributors to this view are: Ford, Ross and Brown [2]; Cockayne and Penrose [3]; McKeown, MacMahon and Record [4, 51. Most recently this view has been advanced by Shim, Campbell and Wright [6]. These autho...