INTRODUCTION Although there is an abundant debate regarding the mechanisms sustaining one of the most common sexual complaints among women, i.e., female hypoactive sexual desire disorder (HSDD), little remains known about the specific neural bases of this disorder. AIM The main goal of this study was to determine whether women with HSDD showed differential patterns of activation within the br...

INTRODUCTION Counts of satisfying sexual events (SSEs) per month have been criticized as an end point in treatment trials of women with hypoactive sexual desire disorder (HSDD) but grounding improvement in sexual desire by assessing changes in sexual behavior remains of some importance. METHODS We conducted a literature review to find validated measurements that are specific sexual behavioral...

Objective: Hypoactive sexual desire Disorder (HSDD) is a common sexual problem among women. Sexual interest and desire inventory -female (SIDI-F) has been widely validated and used to measure sexual desire in women. The aim of this study was to determine the psychometric properties of the Persian version of SIDI-F for Iranian population. Method: This was a methodological study on the psychometr...

INTRODUCTION A validated cutpoint for the total Female Sexual Function Index scale score exists to classify women with and without sexual dysfunction. However, there is no sexual desire (SD) domain-specific cutpoint for assessing the presence of diminished desire in women with or without a sexual desire problem. AIMS This article defines and validates a specific cutpoint on the SD domain for ...

Introduction. A committee of five was convened to update the chapter on women’s sexual dysfunctions from the perspective of diagnostic issues, pathophysiology, assessment, and treatment. Aim. To review the literature since 2003 and provide recommendations based on evidence. Methods. Research databases, conference proceedings, and articles in press were read for relevant new data on these topics...

Flibanserin, a drug with mixed effects on serotonergic and dopaminergic neurotransmitter systems, has recently been recommended for FDA approval, albeit withmany restrictions, for the treatment of low sexual desire in premenopausal women. The sexual side effects of antidepressants with at least partially known mechanisms of action indicate that flibanserin should enhance sexual response. Rather...

Androgens are directly secreted by the ovaries and adrenals in women, and androgen precursors from these glands are converted in a variety of peripheral tissues into androgens. The major androgen in women is testosterone, and its action in target tissues can be mediated through the androgen receptor or through the estrogen receptor after aromatization to estradiol. Low sexual desire that causes...