Exposition to the acute intensive hypobaric hypoxia blocks the triggering mechanism of epileptic seizures only within a short time interval after the end of hypoxia period and it does not influence the progressive epileptogenesis in 12-day-old rats. In 25-day-old rats' hypobaric hypoxia suppresses the postictal depression elicited by the repeated stimulation in short interstimulus intervals and...

The type of pain after laparoscopic surgery differs considerably from that seen after laparotomy. Whereas laparotomy results mostly in parietal pain, patients after laparoscopic cholecystectomy complain more of visceral pain results from the stretching of intraabdominal cavity, peritoneal inflammation and phrenic nerve irritation caused by residual carbon dioxide in the peritoneal cavity. Intra...

BACKGROUND: Potentiating the effect of intrathecal local anesthetics by addition of intrathecal opiods for intra-abdominal surgeries is known. In this study by addition of fentanyl we tried to minimize the dose of bupivacaine, thereby reducing the side effects caused by higher doses of intrathecal bupivacaine in cesarean section. METHODS: Study was performed on 120 cesarean section parturients ...

Bupivacaine is a widely used long-acting local anaesthetic. In clinical practice, a mixture of bupivacaine and lidocaine is often used in order to combine the faster onset of sensory blockade of lidocaine with more profound and longer duration of blockade by bupivacaine. The aim of this study was to compare the cardiotoxicity of large doses of bupivacaine and mixture of bupivacaine with lidocai...

BACKGROUND The aim of the study was to determine the median effective dose (ED50) for motor block of various concentrations of intrathecally administered plain bupivacaine. MATERIAL AND METHODS Between 2011 and 2013, 64 patients aged ≥70 years, undergoing transurethral, or lower limb surgery with combined spinal and epidural anesthesia in a single hospital were enrolled. The patients were ran...

‘Law Rome’ and ‘Granny Smith’ apples were stored hypobarically in air at 5 kPa total pressure and also in air or controlled atmosphere (CA) at 1.5 or 3% O2 with 0 or 3% CO2, for 8 months at 1°C. Fruit were placed under hypobaric storage immediately after harvest or after 0.5, 1, 2, 3, 4, 5 or 6 months storage in air at 1°C to determine the effects of delaying imposition of hypobaric storage on ...

Three solutions administered by continuous extradural infusion for postoperative analgesia were compared in a randomized, double-blind manner. All patients underwent major abdominal gynaecological surgery and received 0.125% bupivacaine in 0.9% saline, diamorphine in 0.9% saline (0.5 mg in 15 ml) or diamorphine mixed with 0.125% bupivacaine (0.5 mg in 15 ml), at a rate of 15 ml h-1. The bupivac...

Background: Several studies on the reduction of pain with use local anesthetics after laparoscopic hernia surgeries have been published. We aimed to analyze results anesthesia applied patients by retrospectively scanning files who underwent total extraperitoneal hernioplasty for inguinal hernias. Methods: The TEP hernias between March 2019 and November 2022 in Ankara Bilkent city hospital gener...

Previous data have established that postsynaptic stimulation of central dopaminergic receptors was mainly involved in the protective action of apomorphine against the comportmental consequences of hypobaric hypoxia in rats: disturbances in a conditioned avoidance response. We confirm this notion showing that domperidone (a peripheral dopaminergic blocking agent) does not antagonize the protecti...

PURPOSE The aim of this study was to evaluate the effect of bupivacaine irrigated at the surgical bed on postoperative pain relief in laparoscopic cholecystectomy patients. METHODS This study included 60 patients undergoing elective laparoscopic cholecystectomy who were prospectively randomized into 2 groups. The placebo group (n=30) received 20cc saline without bupivacaine, installed into t...