X-linked recessive anhidrotic ectodermal dysplasia with immunodeficiency is a developmental and immunologic disorder caused by mutations in nuclear factor-kappaB essential modulator (NEMO), which is essential for nuclear factor-kappaB activation. Early in life, affected boys present a typical appearance, with hypotrichosis or atrichosis, hypohidrosis or anhidrosis, and hypodontia or anodontia w...

INTRODUCTION Hypodontia, agenesis of one or of more teeth, is a common developmental dental anomaly. To date, over 200 candidate genes have been demonstrated to be active in tooth development. The genes Pax9 plays an important role in the initial stage of odontogenesis. Mutations of Pax9 are associated with autosomal dominant forms of oligodontia, the agenesis of more than six teeth and occasio...

Hypodontia, the congenital absence of one or a few teeth, is one of the most common developmental alterations of human dentition. It may cause masticatory and speech dysfunctions and create esthetic problems with orthodontic and prosthetic implications. MMP-9 is an important member of the matrix metalloproteinase (MMP) family that participates in remodeling of extracellular matrix during tooth ...

Anhidrotic ectodermal dysplasia is a triad of hypodontia or anodontia, hypotrichosis, and hypohydrosis, associated with other problems that result from the defective development of structures of ectodermal origin (Freire-Maia, Pinheiro (1988)). Early and extensive dental treatment is needed keeping in mind the effect on the craniofacial growth. Due to rapid growth of the jaws, the patients are ...

Tooth agenesis in the reduction of tooth number which includes hypodontia, oligodontia and anodontia is caused by disturbances and gene mutations that occur during odontogenesis. To date, several genetic mutations that unlock the causes of non-syndromic tooth agenesis are being discovered; these have been associated with certain illnesses because tooth development involves the interaction of se...

The prevalence of hypodontia is reported to be between 1.5% to 10% in the permanent dentition. In the anterior teeth, maxillary lateral incisors and mandibular central incisors are the most frequently involved teeth. This causes esthetic problems for the patient. Several reports have focused on restoration of retained maxillary primary anterior teeth, but none have described restoration of reta...

Central incisor, congenital absence, hypodontia, tooth agenesis. Abstract Hypodontia is the congenital absence of less than six teeth because of agenesis. The absence of teeth may be unilateral or bilateral. There are reports showing unilateral occurrence of permanent mandibular incisors. But agenesis of bilateral mandibular central incisors is not well documented in the literature and comprehe...

This clinical report describes the delayed development of a maxillary second premolar. The premolar developed when the patient was between the ages of 12 and 16 years. The development of the tooth was discovered from a panoramic radiograph taken when the patient was 17 years, 1 month of age. Previous to this discovery, the tooth had been diagnosed as congenitally missing. The transition from th...

OBJECTIVE The aim of this study was to assess the prevalence and pattern of congenital missing teeth in the permanent dentition (excluding wisdom teeth), among Turkish children in a 4-year period (2009-2012). METHODS The study group comprised 1658 children (873 girls, 785 boys). The children were examined in Department of Pediatric Dentistry, Dental School of Marmara University. A chi square ...