Magnesium wasting with hypocalciuria was first described by Geven et al. in 1987. In two presumably unrelated families, serum Mg2+ was found to be as low as 0.39 mmol/L without other plasma electrolyte abnormalities, including calcium (both serum and normal ionized), sodium, potassium, chloride and bicarbonate. Blood pH, renin activity and plasma aldosterone were in the normal range. The only a...

M a key mineral, is the second most abundant intracellular cation. It is a cofactor of various enzymes, is essential for maintenance of membrane potentials and modification of vascular tone.1It helps to maintain normal nerve and muscle function and supports a healthy immune system. The tota l magnes ium content in humans is 25 mEq (12.4 mmol) per kilogram of body weight. The normal serum magnes...

CUTE AND chronic alcoholism are the most common A settings for hypomagnesemia in everyday clinical practice.' In almost all studies addressing this issue, the total serum magnesium concentration was although there are limitations on its use in evaluating total body magnesium stores.' Recently, commercially available instruments with new ion-selective electrodes for ionized magnesium, the biolog...

Background Magnesium (Mg) is essential for life and plays a crucial role in several biochemical and physiological processes in the human body. Hypomagnesemia is common in all hospitalized patients, especially in critically ill patients with coexisting electrolyte abnormalities. Hypomagnesemia may cause severe and potential fatal complications if not timely diagnosed and properly treated, and as...

INTRODUCTION Although magnesium plays an important role in aerobic metabolism and magnesium deficiency is a common phenomenon in critical illness, the association between magnesium deficiency and lactic acidosis in the intensive care unit (ICU) has not been defined. METHODS This was a retrospective, cross-sectional study conducted at a 77 ICU bed tertiary medical center. Data pertaining to th...

The body maintains Mg(2+) homeostasis by renal and intestinal (re)absorption. However, the molecular mechanisms that mediate transepithelial Mg(2+) transport are largely unknown. Transient receptor potential melastatin 6 (TRPM6) was recently identified and shown to function in active epithelial Mg(2+) transport in intestine and kidney. To define the relationship between Mg(2+) status and TRPM6 ...