Recent experimental work has shown that hypothermia with even small decreases in temperature is broadly neuroprotective, but the mechanism of this protection remains unclear. Although reduction of metabolism could explain protection by deep hypothermia, it does not explain the robust protection found with mild hypothermia. Several reports have suggested that ischemic apoptosis is reduced by hyp...

PURPOSE OF REVIEW The aim of this article is to review the current status of protective effects of mild-to-moderate hypothermia on traumatic brain injury. RECENT FINDINGS More than 30 clinical studies have reported effects of therapeutic hypothermia on outcome of traumatic brain injury and cerebral ischemia. Only one clinical trial of short-term mild hypothermia did not show any effect in pat...

Fairchild, Karen D., Ishwar S. Singh, Sandip Patel, Beth E. Drysdale, Rose M. Viscardi, Lisa Hester, Heather M. Lazusky, and Jeffrey D. Hasday. Hypothermia prolongs activation of NFand augments generation of inflammatory cytokines. Am J Physiol Cell Physiol 287: C422–C431, 2004. First published April 7, 2004; 10.1152/ajpcell.00507.2003.—While moderate hypothermia is protective against ischemic ...

OBJECTIVE We evaluated the effects of mild hypothermia (32 degrees C), established before experimental intra-abdominal sepsis, on outcome, cytokine pattern, and muscle tissue oxygenation. DESIGN Clinic modeling randomized laboratory trial. SETTING University laboratory. SUBJECTS Ninety-six male rats. INTERVENTIONS In a group-sequential design, using 42 rats per group, we compared mild h...

Mild therapeutic hypothermia is considered standard care in the treatment of patients resuscitated from cardiac arrest. With increasingly more frequent concomitant use of platelet-inhibiting drugs, clinicians must be cognizant of the ramifications of hypothermia on platelet function as part of hemostasis. The effects of hypothermia on platelet function have been studied for more than 50 years, ...

This article discusses the potential of levosimendan to treat calcium-induced myocardial dysfunction associated with deep hypothermia. Moderate hypothermia (30 to 34°C) usually improves myocardial contractility and stabilizes heart rhythm, but deep hypothermia can cause severe myocardial dysfunction, which is mediated by intracellular calcium overload. In experimental studies, levosimendan appe...

Induced hypothermia (28–32°C) has been indicated for some time for myocardial and cerebral protection in cardiac anaesthesia. However, it has recently been recognised that mild, inadvertent peri-operative hypothermia is associated with a number of adverse postoperative outcomes. Patient outcome can be improved by preventing peri-operative hypothermia. Although there is no clear definition of mi...

In light of the relevance of therapeutic hypothermia to stroke treatment, we investigated whether 5'-adenosine monophosphate (AMP)-dependent cooling affords protection from ischemic brain injury. We show that hypothermia by AMP is because of adenosine A1 receptor (A1R) activation and is not invariantly associated with hypotension. Inhibition of ecto-5'-nucleotidase-dependent constitutive degrad...

Most cases of fatal hypothermia are accidental, often in connection with alcoholisation, homelessness, age-related confusedness and others. The phenomenon of paradoxical undressing may be observed. A paradoxical feeling of warmth in the advanced condition of hypothermia leads to the behaviour of undressing, partly or completely. Suicides with intentional hypothermia are rare. Fatal hypothermia ...

An association is described between hypothermia occurring in anaesthetized babies and early postoperative morbidity and death. Sixty-seven children under one year old had operations in 1960, of whom twelve died; seven of these cases (which are described) were associated with hypothermia. While other factors were undoubtedly involved it seems that hypothermia was the principal factor responsible...