BACKGROUND Recent trials have assessed the efficacy and safety of novel monoclonal antibodies such as reslizumab and benralizumab. However, the overall efficacy and safety anti-interleukin (IL) 5 treatment in asthma have not been thoroughly assessed. METHODS Randomized controlled trials (RCTs) of anti-IL-5 treatment on patients with asthma published up to October 2016 in PubMed, Embase, and C...

BACKGROUND Plasmodium vivax is one of the major species of malaria infecting humans. Although emphasis on P. falciparum is appropriate, the burden of vivax malaria should be given due attention. This study aimed to synthesize the evidence on severe malaria in P. vivax infection compared with that in P. falciparum infection. METHODS/PRINCIPAL FINDINGS We searched relevant studies in electronic...

Abstract Background Sodium glucose cotransporter 2 inhibitors (SGLT2i) have been shown to improve the prognosis of heart failure with preserved ejection fraction (HFpEF) in phase 3 randomized controlled trials (RCTs). However, a granular definition HF was adopted only most recent RCTs (hereafter, RCTs). In earlier studies, which assessed cardiovascular (CV) outcomes patients type diabetes (CV t...

BACKGROUND To update a previously published systematic review and meta-analysis on the efficacy and safety of tubeless percutaneous nephrolithotomy (PCNL). METHODS A systematic literature search of EMBASE, PubMed, Web of Science, and the Cochrane Library was performed to confirm relevant studies. The scientific literature was screened in accordance with the predetermined inclusion and exclusi...

BACKGROUND Although nut consumption has been associated with a reduced risk of cardiovascular disease and all-cause mortality, data on less common causes of death has not been systematically assessed. Previous reviews missed several studies and additional studies have since been published. We therefore conducted a systematic review and meta-analysis of nut consumption and risk of cardiovascular...

AIMS/INTRODUCTION A meta-analysis was carried out to evaluate the efficacy of yoga in adults with type 2 diabetes mellitus. MATERIALS AND METHODS The PubMed, EMBASE and Cochrane databases were searched to obtain eligible randomized controlled trials. The primary outcome was fasting blood glucose, and the secondary outcomes included glycosylated hemoglobin A1c, total cholesterol, high-density ...

PURPOSE We aimed to characterize the antiretroviral therapy (ART) cascade among female sex workers (FSWs) globally. METHODS We systematically searched PubMed, Embase and MEDLINE in March 2014 to identify studies reporting on ART uptake, attrition, adherence, and outcomes (viral suppression or CD4 count improvements) among HIV-infected FSWs globally. When possible, available estimates were poo...

BACKGROUND The rate of alcohol relapse among patients who underwent liver transplantation for alcoholic hepatitis (AH) is not precisely known. AIM Synthesize the available evidence on liver transplantation for AH to assess alcohol relapse and 6-month survival. METHODS Meta-analysis of trials evaluating liver transplantation for AH, either clinically severe or diagnosed on the explant. RES...

INTRODUCTION This systematic review and meta-analysis aimed to evaluate the effect of small bowel feeding compared with gastric feeding on the frequency of pneumonia and other patient-important outcomes in critically ill patients. METHODS We searched EMBASE, MEDLINE, clinicaltrials.gov and personal files from 1980 to Dec 2012, and conferences and proceedings from 1993 to Dec 2012 for randomiz...

The photodissociation dynamics of I2 ~CO2)n(n54 – 16) clusters excited at 780 nm have been studied with femtosecond photoelectron spectroscopy ~FPES!. The range of cluster sizes spans the uncaged and fully-caged product limits for this reaction. We observe time scales for a variety of processes in these clusters, including dissociation of the I2 2 chromophore, solvation of the I fragment, the o...