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This review paper describes methods of protecting the peritoneal membrane in uremic patients chronically treated with peritoneal dialysis. Possible interventions involved in protection of the peritoneum aim at reducing peritoneal exposure to glucose, glucose degradation products and lactate; preventing or diminishing harmful effects of dialysis solutions; decreasing infection rate, especially p...

As the population of chronic kidney disease (CKD) and end-stage renal disease (ESRD) grows at an alarming rate, primary care physicians will increasingly be involved in the management of these patients. Early recognition of CKD and timely referral to a nephrologist when glomerular filtration rate approaches 30 mL/min/1.73 m(2) is extremely important to improve ESRD outcome and appropriate selec...

The first patient, a 68-year-old man, was admitted for peritoneal dialysis (PD) catheter explantation because of ultrafiltration failure and symptoms of bowel obstruction. PD was performed for 30 months with neutral PD fluids and icodextrin. There was a history of two episodes of peritonitis, and a high transporter status. Computed tomography (CT) scan showed ascites, calcifications, and thicke...

INTRODUCTION Postoperative adhesion formation remains a major clinical problem. The aim of this study was to test the effect of a new hydrogel on adhesion formation in a rat model. MATERIALS AND METHODS A reproducible rat model was used to induce standardized adhesion formation in three experiments. In experiment 1, a cross-linked polyvinyl alcohol (PVA) and carboxymethylcellulose (CMC) hydro...

BACKGROUND Peritoneal dialysis fluids (PDFs) have been shown to alter mesothelial cell functions. To further determine the mechanisms involved, we investigated the effects of glucose, glucose degradation products (GDPs) and advanced glycation end products (AGEs) on the inhibition of human peritoneal mesothelial cell (HPMC) proliferation and the induction of apoptosis and oncosis. METHODS Four...