Studies in model organisms have demonstrated that components of insulin and insulin-like signaling pathways are involved in the regulation of lifespan but the relevance of those findings to humans has remained obscure. Here we provide evidence suggesting that variants of the gene encoding insulin-degrading enzyme (IDE) may be influencing human lifespan. We have employed a variety of models and ...

Syntax Display A dockable subwindow displays the abstract syntax tree (AST) of the current buffer. This is shown on the left of Fig. 4, where we define the theory from Ex. 2.2 in LF. Here, the green parts are the keywords and separators of our structure parser (see Sect. 4.1). Users can navigate from a buffer position to the respective node in the AST and vice versa, as shown in the jointly sel...

1. A modified procedure for the isolation of etioplasts from dark-grown barley is described and the regeneration of phototransformable protchlorophyll(ide) was demonstrated in the isolated plastids. 2. On exposure of the etioplasts to a long-term flash illumination, chlorophyll(ide) synthesis from a precursor pool, which includes all the protochlorophyllide, was demonstrated. 3. Added delta-ami...

Software developers faced with unfamiliar objectoriented code need to build a mental model of the system to understand its dynamic flow. Development environments typically provide static views of the source code (e.g., classes and methods), but do not explicitly represent dynamic collaborations. The task of revealing how static source artifacts interact at runtime is thus challenging.To address...

The integrated development environment (IDE) is the primary tool used by developers to maintain software systems. The IDE, however, narrowly focuses on the static structure of a system, neglecting dynamic behavior and dynamic relationships between static source artifacts such as classes and methods. Developers often have difficulties to understand the dynamic aspects of a system just based on t...

T-Clipse is an Integrated Development Environment (IDE) using Eclipse developed for TwoLevel Grammar (TLG), a high-level formal specification language. In our research, given a programming language, TLG is used to specify the syntax and semantics of the language to generate an interpreter for that language. This IDE provides a user-friendly environment for editing and navigation of TLG source c...

Recent studies suggest that insulin-degrading enzyme (IDE) in neurons and microglia degrades Abeta, the principal component of beta-amyloid and one of the neuropathological hallmarks of Alzheimer's disease (AD). We performed parametric and nonparametric linkage analyses of seven genetic markers on chromosome 10q, six of which map near the IDE gene, in 435 multiplex AD families. These analyses r...

The goal of this project is to develop a web based Integrated Development Environment (IDE). The client only needs a web browser and an internet connection. By connecting to the server, an IDE looking page is downloaded by the browser that looks like and has the functionality of an IDE environment. The client is able to access previous code stored in the database or create new projects, compile...

This paper reports on conception, simulation, and fabrication of a lead zirconate titanate (PZT) MEMS cantilevers for piezoelectric energy harvesting (EH). We investigate the advantages of interdigitated electrode configurations (IDE) with respect to parallel-plate electrodes (PPE) in terms of output voltage and output power from the constitutive equations of piezoelectricity. Finite element mo...