Chronic inflammation contributes to tumor development through the induction of oncogenic mutations, genomic instability, early tumor promotion, and enhanced angiogenesis. Here, we report that IL-1 receptor 1 (IL-1R1) was expressed in 40 of 41 human tongue squamous cell carcinomas (TSCC). IL-1β up-regulated the expression of CXCR4, a CXC chemokine receptor that mediates cancer growth and metasta...

Alcoholic liver disease (ALD) is characterized by steatosis and upregulation of proinflammatory cytokines, including IL-1β. IL-1β, type I IL-1 receptor (IL-1R1), and IL-1 receptor antagonist (IL-1Ra) are all important regulators of the IL-1 signaling complex, which plays a role in inflammation. Furthermore, IL-1β maturation is dependent on caspase-1 (Casp-1). Using IL-1Ra-treated mice as well a...

Natural Killer T (NKT) cells are distinct T cell subset that link innate and adaptive immune responses. IL-1β, produced by various immune cells, plays a key role in the regulation of innate immunity in vivo. However, it is unclear whether NKT cells regulate IL-1β production by macrophages. To address this, we co-cultured NKT cells and peritoneal macrophages in the presence of TCR stimulation an...

the aim of this study was to examine the association of 22 cytokine gene polymorphism in macedonians with chronic obstructive pulmonary disease (copd). the sample of the population comprised of 301 normal respondents and 62 patients with copd. cytokine genotyping was performed by polymerase chain reaction with sequence-specific priming (pcr-ssp). positive (susceptible) association was found bet...

I n 2005, the description of a new subset of effector CD4 + T cells called Th17 broke the Th1/Th2 paradigm. Since then, Th17 cells and their eponymous cytokine interleukin (IL)-17 have emerged as central players underlying not only inflammatory and autoimmune processes but also host resistance to several infections. A selected group of pro-inflammatory cytokines including IL-1β, IL-6 and IL-23 ...

Objectives Osteoarthritis (OA) is a chronic joint disease characterized by osteoproliferation and the degeneration destruction of articular cartilage. Platelet-rich plasma (PRP) rich in various growth factors that have been reported to promote bone defect repair. This study examined specific role mechanism PRP OA. Methods OA model cells were created treating chondrocytes with IL-1β. After treat...

Aim . To study the levels of pro-inflammatory biomarkers in patients with obstructive and non-obstructive coronary artery disease (CAD), to identify possible differences for diagnosing degree obstruction. Material methods The observational included two groups patients: (main group, stenosis <50%; n=30) (comparison hemodynamically significant according results angiography; CAD. interleukin-1β...

In the immune system, interleukin (IL)-1β effects are mediated by the type I IL-1 receptors (IL-1RI), whereas the type II IL-1 receptors (IL-1RII) act as inhibitory receptors. IL-1RI and IL-1RII are also present in the brain. To study their functionality in the brain, mice were centrally treated with neutralizing monoclonal antibody (MAb) directed against IL-1RI (35F5, 1 μg) or against IL-1RII ...

Proinflammatory cytokines are critically involved in the alteration of adipose tissue biology leading to deterioration of glucose homeostasis in obesity. Here we show a pronounced proinflammatory signature of adipose tissue macrophages in type 2 diabetic obese patients, mainly driven by increased NLRP3-dependent interleukin (IL)-1β production. IL-1β release increased with glycemic deterioration...

objective(s) using herbal medicines as a complementary treatment method is increasing in wide variety of diseases. ms14-an herbal-marine preparation-is reported to have anti-inflammatory and immunomodulatory activities; however, the mechanism underlying its therapeutic effect is not known. macrophages play an important role in host defense mechanisms and carry out their role by producing variou...