Purpose High-mobility group box-1 (HMGB1) is a nonhistone DNA-binding nuclear protein released from necrotic cells, which is also secreted by activated leukocytes and acts as a primary proinflammatory cytokine. In this study, we compared vitreous HMGB1 levels in ocular sarcoidosis with those in noninflammatory vitreoretinal diseases and evaluated its association with Th cell-related and proinfl...

objective: astrocytes are the most abundant glial cell type. they may promote or inhibit cns inflammation depending on which cytokines are secreted. astrocytes also have immune roles. il-19, il-20, and il-24 activate a heterodimer receptor composed of the il-20r1 α-chain and the il-20r2 β-chain. it has long been considered that signaling by these receptor complexes affects immunological reactio...

We analyzed the expression of myelomonocytic-associated antigens on lymphocytes from B cell chronic lymphocytic leukemia (B-CLL) patients. Blood mononuclear cells were depleted of monocytes by one-step Percoll density gradient centrifugation and tested for antigen expression by fluorescent microscopy and flow cytometry. The reactivity of patient lymphocytes was as follows: 26 of 31 were positiv...

Gastric cancer is one of the most common malignancies worldwide. Interleukin-1-beta (IL-1β) is a pro-inflammatory cytokine and potent inhibitor of gastric acid secretion. Some studies provided evidence of the association between IL-1B 31 polymorphism and gastric cancer risk while other studies did not. Therefore, we conducted a comprehensive meta-analysis to reassess the association. A systemat...

BACKGROUND We sought to define the sensitivity and specificity of intraperitoneal (IP) and intraluminal (IL) microdialysate metabolites in depicting ex vivo small intestinal total ischemia during GI-tract surgery. We hypothesized that IL as opposed to IP microdialysis detects small intestinal ischemia with higher sensitivity and specificity. METHODS IL and IP microdialysate lactate, pyruvate,...

BACKGROUND Pruritus is a characteristic clinical sign of allergic skin conditions including atopic dermatitis (AD) in the dog. IL-31 is a cytokine found in the serum of some dogs with AD and can induce pruritic behaviours in laboratory beagle dogs. HYPOTHESIS/OBJECTIVES The objectives were to characterize an IL-31-induced pruritus model by evaluating the efficacy of prednisolone, dexamethason...

PURPOSE Atopic dermatitis (AD) is a chronic inflammatory relapsing skin disorder. Vitamin D plays a pivotal role in the development of AD, and interleukin (IL) 31 is known to be related to pruritus in AD. The aim of our study was to determine whether 25-hydroxyvitamin D (25(OH)D) levels are related to IL-31 levels or to the severity of AD. METHODS We enrolled 91 children with AD and 32 contro...

it has been shown that activated t-cells produce and release both il-2 and il- 2 receptors (ll-2r). the rate of il-2 release is proportional to its cell surface expression and state of cell activation. to clarify the molecular basis of this immunological aberration, we analysed the amount of soluble il-2r(sil2-r) by an elisa technique in 68 patients with behcet's disease (bd), 28 patient c...