In neuropathic pain the repeated minocycline treatment inhibited the mRNA and protein expression of the microglial markers and metalloproteinase-9 (MMP-9). The minocycline diminished the pronociceptive (IL-6, IL-18), but not antinociceptive (IL-1alpha, IL-4, IL-10) cytokines at the spinal cord level. In vitro primary cell culture studies have shown that MMP-9, TIMP-1, IL-1beta, IL-1alpha, IL-6,...

OBJECTIVE Mind-body training (MBT) may control reactions to stress and regulate the nervous and immune systems. The present study was designed to assess the effects of MBT on plasma cytokines and their interactions with catecholamines. METHODS The study group consisted of 80 subjects who practice MBT and a control group of 62 healthy subjects. Plasma catecholamine (norepinephrine, NE; epineph...

Abstract Aims: To investigate the effect of Myrtenol, the active ingredient of Myrtle, on the oxidant and anti-oxidant indices and cytokines in the allergic asthma. Methods: Allergic asthma was induced by ovalbumin (OVA) sensitization and inhalation in four groups of rats; Control, Asthma, Asthma+Dexamethasone and Asthma+Myrtenol. Myrtenol (50mg/kg) or Dexamethasone (2.5mg/kg) was a...

In the present work, an efficient modified carbon-ceramic electrode by multi-walled carbon nanotubes/ionic liquid nanocomposite (MWCNTs/IL/CCE) was prepared through a simple and repeatable procedure. The introduced modified electrode was used for the study of the electrochemical behaviour and determination of tryptophan (Trp) in the presence of uric acid (UA) using cyclic voltammetry (CV), diff...

objective(s):il-12 as an anti-tumor cytokine and il-33 a novel identified cytokine with both pro- or anti-tumor activities, play important roles in response against tumor cells. our aim was to evaluate the il-12 and il-33 levels and single nucleotide polymorphisms (snp) in their genes in patients with breast cancer. materials and methods:blood samples were collected from 100 patients with breas...

objective(s): the effect of prolonged overtraining on cytokine kinetics was compared with moderate exercise in the present study.   materials and methods: male wistar rats were randomly divided into control sedentary (c), moderate trained (mt), (v=20 m/min, 30 min/day for 6 days a week, 8 weeks), overtrained (ot) (v=25 m/min, 60min/day for 6 days a week, 11 weeks) and recovered overtrained (or)...

Both corticotropin releasing hormone (CRH) and serotonin (5-HT) participate in the stress response and are known to modulate cytokine release by human immune cells. Extracellular 5-HT concentrations at or above the serum values have negative immunoregulatory effects by inhibiting the production of interferon-gamma (IFNgamma), a pro-inflammatory cytokine produced by Th-1-like lymphocytes, wherea...

The aim of the research was to determine differences in IL-1ß, IL-2, IL-4, IL-10, IL-17, INF-γ, TNF-α and IL-1ra blood concentrations pregnant non-pregnant healthy mares. mares were divided into two groups: (n = 18; age 6.11 ± 2.25 years); 6; 5.67 1.75 years). Blood samples collected from all 24) three times every month, then group subgroups based on pregnancy (1st 6)—6th, 7th, 8th; 2nd 6)—7th,...