Approximately 40% of chronic myeloid leukemia (CML) patients who discontinue imatinib (IM) therapy maintain undetectable minimal residual disease (UMRD) for more than one year (stopping IM (STOP-IM)). To determine a possible biomarker for STOP-IM CML, we examined plasma miRNA expression in CML patients who were able to discontinue IM. We first screened candidate miRNAs in unselected STOP-IM pat...

N-methylpyrrole (Py)-N-methylimidazole (Im) polyamides are small organic molecules that bind to DNA with sequence specificity and can be used as synthetic DNA-binding ligands. In this study, five hairpin eight-ring Py-Im polyamides 1-5 with different number of Im rings were synthesized, and their binding behaviour was investigated with surface plasmon resonance assay. It was found that associat...

BACKGROUND A subset of patients with chronic myeloid leukemia (CML) can sustain a complete molecular response after discontinuing imatinib mesylate (IM). We focused on microRNAs (miRNAs), with the aim of finding a molecular biomarker to discriminate which patients can safely and successfully discontinue IM use. METHODS To identify miRNAs that showed altered expression in patients who had disc...

background: previous studies reported that neonatal and maternal complications as well as duration of labor could be diminished through labor management. therefore, we aimed to evaluate the effect of intramuscular (im) administration of atropine and hyoscine combination on labor progress and maternal and neonatal outcomes in primigravid women admitted to taleghani hospital of arak, iran. method...

This study examined the relationship between reticence (Keaten & Kelly, 2000) and instant messaging (IM), including affect for IM, usage of IM, and self-perceived competence using IM in difficult interpersonal situations. Participants (N 1⁄4 336) from undergraduate courses responded to self-report measures of reticence, affect for IM, general usage of IM, as well as usage in challenging interpe...

introduction : the aim of this study is to evaluate the effect of a newly introduced nanosilver based irrigant on dentin roughness in comparison with three commonly used root canal irrigants. material and methods : irrigants tested were: naocl 5.25%, edta 17%, chx 2% and newly introduced imidazolium-based silver nanoparticle (im agnp) irrigant at 5.8×10 -8 mol/l. distilled water was used as con...

background: this study was conducted to evaluate the effect of chronic exposure to imidacloprid (im) insecticide on male testicular tissue, sperm morphology and testosterone levels in the serum of mature male rats. materials and methods: animals were divided into and control-sham groups. the test group was subdivided into two groups of rats which were administered doses of 225 and 112 mg/kg im ...

conclusions the educational framework provided by im for at training improved attitude and behavioral beliefs that can facilitate the adoption of at behavior and decreased clbp. results significant differences were recorded before and after intervention (p < 0.001) for the model constructs of intention, perceived risk, direct attitude, behavioral beliefs, and knowledge in both groups. direct at...

Background. We describe the process and challenges of delivering integrative medicine (IM) at a large, acute care hospital, from the perspectives of IM practitioners. To date, minimal literature that addresses the delivery of IM care in an inpatient setting from this perspective exists. Methods. Fifteen IM practitioners were interviewed about their experience delivering IM services at Abbott No...