The problems considered in the review are: mechanisms of formation physiological and pathological endothelium phenotypes, involvment hematovascular homeostasis, immune processes, inflammation, systemic inflammatory response. reversibility endothelial dysfunction, participation reaction, etc. are discussed. validity conventional term «endotheliitis» for dysfunction various diseases, including CO...

Immunotherapy shows promising clinical results in patients with different types of cancer, but its full potential is not reached due to immune dysfunction as a result of several suppressive mechanisms that play a role in cancer development and progression. Monitoring of immune dysfunction is a prerequisite for the development of strategies aiming to alleviate cancer-induced immune suppression. ...

Background: The direct effect of some opioids on immune cells has been demonstrated. The aim of this study was to assess the apoptotic effect of opium on Jurkat T lymphocyte cells. Methods: Different concentrations of opium (2.86 × 10-3 to 2.86 × 10-11 g/ml) were added to 24-well plates containing 5 × 105 Jurkat cells. Apoptotic events were assessed after 6, 24, and 72 hours by flow-cytometric...

HIV-1 disease progression is paradoxically characterized by systemic chronic immune activation and gut mucosal immune dysfunction, which is not fully defined. Annexin A1 (ANXA1), an inflammation modulator, is a potential link between systemic inflammation and gut immune dysfunction during the simian immunodeficiency virus (SIV) infection. Gene expression of ANXA1 and cytokines were assessed in ...

Adipose tissue (AT) dysfunction, characterized by loss of its homeostatic functions, is a hallmark of non-communicable diseases. It is characterized by chronic low-grade inflammation and is observed in obesity, metabolic disorders such as insulin resistance and diabetes. While classically it has been identified by increased cytokine or chemokine expression, such as increased MCP-1, RANTES, IL-6...

In the tumor immune microenvironment, CD8+ T cells differentiate towards functional failure. The exhaustion of (Tex) showed varying degrees effect dysfunction, loss proliferation ability, and sustained high expression a variety inhibitory receptors, with metabolic epigenetic changes. Tex are heterogeneous, including several subsets different characteristics at stages differentiation. Immune che...

Abstract The elderly are at the greatest risk for severe endotoxemia and bacterial infections. increase in low grade chronic inflammation decline of immune response during aging contributes to this disease severity. Visceral adipose tissue (vWAT) exhibits recruitment activation pathogen challenge metabolic diseases. Immune cells regulate lipolysis vWAT which is required regulation inflammation,...